机构：[1]Department of Rheumatology & Allergy,Xuanwu Hospital, Capital Medical University,Beijing, China内科系统风湿免疫科首都医科大学宣武医院[2]Clinical Research Centre, Zhujiang Hospitalof Southern Medical University, Guangzhou,China南方医科大学珠江医院[3]Department of Orthopaedics, ZhujiangHospital, Southern Medical University,Guangzhou, China[4]Menzies Institute for Medical Research,University of Tasmania, Hobart, Tasmania,Australia[5]Department of Orthopaedics, the FirstAffiliated Hospital of Anhui MedicalUniversity, Anhui, China[6]Department of Orthopaedics, the FourthAffiliated Hospital of Anhui MedicalUniversity, Anhui, China[7]University of Arizona Arthritis Center &Division of Rheumatology, University ofArizona College of Medicine, Tucson,Arizona, USA[8]Department of Rheumatology, Royal NorthShore Hospital and Institute of Bone and JointResearch, Kolling Institute, University ofSydney, Australia
The study aimed to determine the associations between the morphological types of proximal tibiofibular joint (PTFJ) and the risk of total knee replacement (TKR) in a cohort of participants with progressive osteoarthritis. A nested case-control design was performed in Osteoarthritis Initiative study. The case knees were those with TKR at 24-60 months follow up (cases), and were 1:1 matched with control knees by age, sex, and Kellgren-Lawrence grade at baseline. The morphological type of each PTFJ was identified according to the coronal and sagittal MR images. Conditional logistic regression models were used to examine the association of the PTFJ types with the risk of TKR at baseline and the time point before TKR (T-0). A total of 193 case knees at baseline and 148 case knees at T-0 time point had matched controls between 12 and 60 M. Seven types of the PTFJ were identified and classified into three categories: plane, trochoid, and irregular types. The prevalence of the irregular type was higher in case knees than in controls both at baseline (cases vs. controls, 35.8% vs. 26.9%) and at T-0 time point (cases vs. controls, 33.1% vs. 27.0%). The irregular type of the PTFJ at baseline (odds ratio: 1.62, 95% confidence interval: 1.01-2.59) rather than at T-0 time point was significantly associated with increased odds of TKR. The irregular types of the PTFJ at baseline are associated with increased risk of TKR, suggesting PTFJ may play a role in knee osteoarthritis.
基金：
GlaxoSmithKline; Merck Co., Inc.; Novartis Pharmaceuticals Corporation; Pfizer; NIH's National Heart, Lung, and Blood Institute
第一作者机构：[1]Department of Rheumatology & Allergy,Xuanwu Hospital, Capital Medical University,Beijing, China[2]Clinical Research Centre, Zhujiang Hospitalof Southern Medical University, Guangzhou,China
共同第一作者：
通讯作者：
通讯机构：[2]Clinical Research Centre, Zhujiang Hospitalof Southern Medical University, Guangzhou,China[4]Menzies Institute for Medical Research,University of Tasmania, Hobart, Tasmania,Australia[*1]Clinical Research Centre, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
推荐引用方式(GB/T 7714)：
Zhao Yi,Zhu Zhaohua,Lu Ming,et al.Irregular types of proximal tibiofibular joint increase the risk of total knee replacement: Data from the osteoarthritis initiative[J].JOURNAL OF ORTHOPAEDIC RESEARCH.2022,40(8):1787-1793.doi:10.1002/jor.25204.
APA：
Zhao, Yi,Zhu, Zhaohua,Lu, Ming,Chang, Jun,Zheng, Shuang...&Ding, Changhai.(2022).Irregular types of proximal tibiofibular joint increase the risk of total knee replacement: Data from the osteoarthritis initiative.JOURNAL OF ORTHOPAEDIC RESEARCH,40,(8)
MLA：
Zhao, Yi,et al."Irregular types of proximal tibiofibular joint increase the risk of total knee replacement: Data from the osteoarthritis initiative".JOURNAL OF ORTHOPAEDIC RESEARCH 40..8(2022):1787-1793
