当前位置: 首页 > 详情页

Neural regeneration therapy after spinal cord injury induces unique brain functional reorganizations in rhesus monkeys

文献详情

资源类型:
WOS体系:
Pubmed体系:

收录情况: ◇ SCIE

机构: [1]Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Beijing Key Lab Biomat & Neural Regenerat, Sch Biol Sci & Med Engn, Beijing, Peoples R China [2]China Rehabil Sci Inst, Inst Rehabil Engn, Beijing, Peoples R China [3]Capital Med Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing, Peoples R China [4]Capital Med Univ, Xuanwu Hosp, Dept Anesthesiol, Beijing, Peoples R China [5]Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China [6]Hefei Comprehens Natl Sci Ctr, Inst Artificial Intelligence, Hefei, Peoples R China [7]Univ Chinese Acad Sci, Coll Life Sci, Dept Biol, Beijing, Peoples R China
出处:
ISSN:

关键词: Nonhuman primate neural regeneration sensorimotor cortex causal interactions reorganization

摘要:
Purpose Spinal cord injury (SCI) destroys the sensorimotor pathway and induces brain plasticity. However, the effect of treatment-induced spinal cord tissue regeneration on brain functional reorganization remains unclear. This study was designed to investigate the large-scale functional interactions in the brains of adult female Rhesus monkeys with injured and regenerated thoracic spinal cord. Materials and methods Resting-state functional magnetic resonance imaging (fMRI) combined with Granger Causality analysis (GCA) and motor behaviour analysis were used to assess the causal interaction between sensorimotor cortices, and calculate the relationship between causal interaction and hindlimb stepping in nine Rhesus monkeys undergoing lesion-induced spontaneous recovery (injured, n = 4) and neurotrophin-3/chitosan transplantation-induced regeneration (NT3-chitosan, n = 5) after SCI. Results The results showed that the injured and NT3-chitosan-treated animals had distinct spatiotemporal features of brain functional reorganization. The spontaneous recovery followed the model of "early intra-hemispheric reorganization dominant, late inter-hemispheric reorganization dominant", whereas regenerative therapy animals showed the opposite trend. Although the variation degree of information flow intensity was consistent, the tendency and the relationship between local neuronal activity properties and coupling strength were different between the two groups. In addition, the injured and NT3-chitosan-treated animals had similar motor adjustments but various relationship modes between motor performance and information flow intensity. Conclusions Our findings show that brain functional reorganization induced by regeneration therapy differed from spontaneous recovery after SCI. The influence of unique changes in brain plasticity on the therapeutic effects of future regeneration therapy strategies should be considered. Key messages Neural regeneration elicited a unique spatiotemporal mode of brain functional reorganization in the spinal cord injured monkeys, and that regeneration does not simply reverse the process of brain plasticity induced by spinal cord injury (SCI). Independent "properties of local activity - intensity of information flow" relationships between the injured and treated animals indicating that spontaneous recovery and regenerative therapy exerted different effects on the reorganization of the motor network after SCI. A specific information flow from the left thalamus to the right insular can serve as an indicator to reflect a heterogeneous "information flow - motor performance" relationship between injured and treated animals at similar motor adjustments.

基金:

基金编号: 31970970 31900980 31730030 31730039 U21A20388 31130022 KZ201810025030 2017YFC1104001 2017YFC1104002 2019YFA0707103 2020AAA0105601 Z181100001818007 ZDBS-LYSM028 2021CZ-10 2022CZ12 YWF-22-L-811

语种:
被引次数:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2021]版:
大类 | 3 区 医学
小类 | 2 区 医学:内科
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 医学:内科
JCR分区:
出版当年[2020]版:
Q1 MEDICINE, GENERAL & INTERNAL
最新[2023]版:
Q1 MEDICINE, GENERAL & INTERNAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者:
第一作者机构: [1]Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Beijing Key Lab Biomat & Neural Regenerat, Sch Biol Sci & Med Engn, Beijing, Peoples R China
共同第一作者:
通讯作者:
通讯机构: [5]Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China [6]Hefei Comprehens Natl Sci Ctr, Inst Artificial Intelligence, Hefei, Peoples R China [7]Univ Chinese Acad Sci, Coll Life Sci, Dept Biol, Beijing, Peoples R China
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:16461 今日访问量:0 总访问量:871 更新日期:2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持:重庆聚合科技有限公司 地址:北京市西城区长椿街45号宣武医院