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Structural network alterations induced by ART-naive and ART-treated subjects infected with HIV

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收录情况： ◇ SCIE

作者：
Liu Jiaojiao[1] * ; Wang Wei[1] * ; Wang Yuanyuan[2] * ; Liu Mingming[3] ; Liu Dan[4] ; Li Ruili[5] ; Cai Chao[1] ; Sun Lijun[1] ; Gao Quansheng[6] ; Li Hongjun[1,*1] ;
机构： [1]Beijign Youan Hospital, Capital Medical University, Beijing, 100069, China [2]Beijing Second Hospital, Beijing, 100032, China [3]Cangzhou Central Hospital, Hebei, 061001, China [4]Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200000, China [5]Beijing Xuanwu Hospital, Capital Medical University, Beijing, 100000, China [6]Institute of Environmental Medicine and Occupational Medicine, Academy of Military Medical Sciences, Tianjin, 300050, China
出处：
DOI： 10.1016/j.bbrc.2022.06.078
ISSN：

摘要：
To investigate how the structural connectivity altered in combined antiretroviral therapy-treated (cART+) HIV patients and cART-naive (cART-) HIV patients by conducting Network analysis of Diffusion Tensor Imaging (DTI) data.We enrolled 22 cART-, 23 cART+ and 28 normal controls (NC) in our current study. Firstly, the DTI imaging data pre-processing was conducted and the asymmetric 90 × 90 matrix for each participant from their DTI data was obtained with the use of PANDA. Then, we applied a graph-theoretical network analysis toolkit, GRETNA v2.0, to calculate metrics such as small-"worldness," characteristic path length, clustering coefficient, global efficiency, local efficiency, and nodal "betweenness". Finally, we took comparisons among the three groups to investigate topological alterations.Results (1) the regional characteristics (nodal efficiency) were altered in cART- and cART+ patients predominantly in the frontal cortical regions; (2) changes in various network properties in cART+treat and cART-patients were associated with the performance of behavior functions; (3) Hubs redistributed in HIV subjects especially in cART+ patients.The regional characteristics (nodal efficiency) were altered in cART- and cART+ patients predominantly in the frontal cortical region, and changes in various network properties in cART- and cART+ patients were associated with the performance of behavior functions. In addition, Hubs redistributed in HIV subjects especially in cART+ patients.Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

基金：
This work was supported by the National Natural Science Foundation of China (grant no. 61936013); the Beijing Natural Science Foundation (7212051).
语种：
外文
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中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 生物学
小类 | 3 区 生物物理 4 区 生化与分子生物学
最新[2025]版：
大类 | 4 区 生物学
小类 | 4 区 生化与分子生物学 4 区 生物物理
JCR分区：
出版当年[2020]版：
Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Beijign Youan Hospital, Capital Medical University, Beijing, 100069, China
共同第一作者：
通讯作者：
通讯机构： [1]Beijign Youan Hospital, Capital Medical University, Beijing, 100069, China [*1]Beijing YouAn Hospital, Capital Medical University, Beijing, 100069, China.
推荐引用方式(GB/T 7714)：
Liu Jiaojiao,Wang Wei,Wang Yuanyuan,et al.Structural network alterations induced by ART-naive and ART-treated subjects infected with HIV[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2022,622:115-121.doi:10.1016/j.bbrc.2022.06.078.
APA：
Liu Jiaojiao,Wang Wei,Wang Yuanyuan,Liu Mingming,Liu Dan...&Li Hongjun.(2022).Structural network alterations induced by ART-naive and ART-treated subjects infected with HIV.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,622,
MLA：
Liu Jiaojiao,et al."Structural network alterations induced by ART-naive and ART-treated subjects infected with HIV".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 622.(2022):115-121

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