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Identification of protein biomarkers in host cerebrospinal fluid for differential diagnosis of tuberculous meningitis and other meningitis

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机构： [1]Tuberculosis Department, Beijing Chest Hospital, Capital Medical University, Beijing, China. [2]Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China. [3]Neurology Department, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. [4]Department of Emergency Medicine, Beijing Chest Hospital, Capital Medical University, Beijing, China. [5]Neurology Department, Xuanwu Hospital, Capital Medical University, Beijing, China. [6]Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing, China.

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The diagnosis of tuberculous meningitis (TBM) is difficult due to the lack of sensitive methods. Identification of TBM-specific biomarkers in the cerebrospinal fluid (CSF) may help diagnose and improve our understanding of TBM pathogenesis.Of the 112 suspected patients with TBM prospectively enrolled in the study, 32 patients with inconclusive diagnosis, non-infectious meningitis, and long-term treatment with hormones and immunosuppressants were excluded. The expression of 8 proteins in the CSF was analyzed using ELISA in 22 patients with definite TBM, 18 patients with probable TBM, and 40 patients with non-TBM.Significant differences in the expression of 7 proteins were detected between the TBM and non-TBM groups (P < 0.01). Unsupervised hierarchical clustering (UHC) analysis revealed a disease-specific profile consisting of 7 differentially expressed proteins for TBM diagnosis, with an accuracy of 82.5% (66/80). Logistic regression with forward stepwise analysis indicated that a combination of 3 biomarkers (APOE_APOAI_S100A8) showed a better ability to discriminate TBM from patients with non-TBM [area under the curve (AUC) = 0.916 (95%CI: 0.857-0.976)], with a sensitivity of 95.0% (95%CI: 83.1-99.4%) and a specificity of 77.5% (95%CI: 61.5-89.2%).Our results confirmed the potential ability of CSF proteins to distinguish TBM from patients with non-TBM and provided a useful panel for the diagnosis of TBM.Copyright © 2022 Huang, Ding, Li, Chen, Du, Jia, Sun, Du, Wei, Xing, Li, Chu and Pan.

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出版当年[2021]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

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出版当年[2020]版：

Q2 NEUROSCIENCES Q2 CLINICAL NEUROLOGY

最新[2023]版：

Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

影响因子： 2.7 最新[2023版] 3.3 最新五年平均 4.003 出版当年[2020版] 4.189 出版当年五年平均 2.889 出版前一年[2019版] 4.086 出版后一年[2021版]

第一作者：

第一作者机构： [1]Tuberculosis Department, Beijing Chest Hospital, Capital Medical University, Beijing, China. [2]Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.

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通讯作者：

通讯机构： [2]Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China. [6]Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing, China.

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