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The core autophagy protein ATG5 controls the polarity of the Golgi apparatus and insulin secretion of pancreatic beta cells

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收录情况： ◇ SCIE

作者：
Pei Xintong[1,2] * ; Wang Huiyu[1] * ; Xu Pingyong[1,2,3,4] ; Liang Kuo[5] ; Yuan Lin[1] ;
机构： [1]Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China [2]College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100101, China [3]National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China [4]Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China [5]Department of General Surgery, XuanWu Hospital, Capital Medical University, Beijing, China
出处：
DOI： 10.1016/j.bbrc.2022.08.084
ISSN：

摘要：
Pancreatic beta cells are insulin-producing cells that are structurally and functionally polarized in the islets of Langerhans. The organization and position of the Golgi complex play a key role in maintaining a polarized cell state, but the factors and molecular mechanisms determining the Golgi polarization of pancreatic beta cells are still unknown. In the current study, using pancreatic beta cell-specific Atg5 knockout mice, we found that Atg5, an essential gene for autophagy, plays a pivotal role in regulating Golgi integrity and polarization by affecting the expression of genes involved in vesicle transport. Deletion of Atg5 led to endoplasmic reticulum (ER) stress and impaired the distribution of proinsulin and insulin secretion of pancreatic beta cells, which further exacerbates diabetes. These results contribute to a comprehensive understanding of autophagy-mediated Golgi polarization and its regulation of the function of pancreatic beta cells.Copyright © 2022 Elsevier Inc. All rights reserved.

基金：
This project was supported by the National Natural Science Foundation of China (31970704, 21927813 and 32027901), the Strategic Priority Research Programof Chinese Academy of Sciences (XDB37040301) and the Beijing Natural Science Foundation (7182063). We thank Dr. Noboru Mizushima, Tokyo University and Dr. Weiping Zhang, Second Military Medical University for providing the mice harboring LoxP sites flanking exon 3 of the Atg5 gene and the mice expressing Cre recombinase under the control of Ins2, respectively. We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript
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外文
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中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 生物学
小类 | 3 区 生物物理 4 区 生化与分子生物学
最新[2023]版：
大类 | 3 区 生物学
小类 | 3 区 生物物理 4 区 生化与分子生物学
JCR分区：
出版当年[2020]版：
Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China [2]College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100101, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Pei Xintong,Wang Huiyu,Xu Pingyong,et al.The core autophagy protein ATG5 controls the polarity of the Golgi apparatus and insulin secretion of pancreatic beta cells[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2022,629:26-33.doi:10.1016/j.bbrc.2022.08.084.
APA：
Pei Xintong,Wang Huiyu,Xu Pingyong,Liang Kuo&Yuan Lin.(2022).The core autophagy protein ATG5 controls the polarity of the Golgi apparatus and insulin secretion of pancreatic beta cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,629,
MLA：
Pei Xintong,et al."The core autophagy protein ATG5 controls the polarity of the Golgi apparatus and insulin secretion of pancreatic beta cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 629.(2022):26-33

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