机构：[1]Department of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine, No. 6 Fangxingyuan 1st Block, Fengtai District, Beijing 100078, China China[2]Department of Neurobiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053, China首都医科大学宣武医院[3]Department of Acupuncture, General Hospital of the People’s Liberation Army, No. 28, Fuxing Road, Haidian District, Beijing 100853, China[4]Affiliated Hospital of Guilin Medical University, No. 15, Lequn Road, Guilin, Guangxi 541001, China[5]China Academy of Chinese Medical Sciences Guang’anmen Hospital, No. 5, North Line Pavilion, Xicheng District, Beijing 100053, China[6]Beijing Parkcare Technology Co Ltd, No. 18, Xihuan South Road, Beijing Economic and Technological Development Zone, Beijing 100176, China[7]Department of Neurology, Xi’an Traditional Chinese Medicine Hospital, No. 69, Fengcheng Eighth Road, Xi’an, Shaanxi 710021, China
Previous studies have shown that alpha-synuclein (alpha-syn) accumulation in the normal aging brain is associated with a parallel increase in hemoglobin-binding alpha-syn (Hb-alpha-syn) in the brain and peripheral erythrocytes (ERCs), indicating that Hb-alpha-syn levels in ERCs may reflect the alpha-syn changes in the brain. However, if there is any change in ERC Hb-alpha-syn levels in disease condition is unclear. In this study, Hb-alpha-syn levels in ERCs from 149 Patients with multiple system atrophy (MSA) and 149 healthy controls (HCs) were measured by enzyme linked immunosorbent assay (ELISA). The results showed that Hb-alpha-syn levels in ERCs were significantly increased in MSA patients in comparison with those in HCs (777.84 & PLUSMN; 240.82 ng/mg vs 508.84 & PLUSMN; 162.57 ng/mg, P < 0.001). Receiver operating characteristic curve (ROC) indicated that increased Hb-alpha-syn in ERCs could discriminate MSA patients from HCs, with a sensitivity of 71.8%, a specificity of 80.5%, and an area under the curve (AUC) of 0.837. The positive and negative predictive values at a cut-off value of 616.12 ng/mg were 78.7% and 74.1%, respectively. However, the increase in Hb-alpha-syn levels did not show any association with the age of onset and consultation, disease duration, and UMSARS (I-IV) score. This pilot study suggests that ERC Hb-alpha-syn is increased in MSA patients and could evaluate alpha-syn accumulation in the brain of patients.
基金：
Capital Health Research and Development of Special [2018-2-4202]; Key Research Project of Beijing University of Chi-nese Medicine [2020-JYB-ZDGG-119]; Guangxi Key Program for Science and Technology Project of China [AB18221039]
第一作者机构：[1]Department of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine, No. 6 Fangxingyuan 1st Block, Fengtai District, Beijing 100078, China China
通讯作者：
通讯机构：[1]Department of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine, No. 6 Fangxingyuan 1st Block, Fengtai District, Beijing 100078, China China[2]Department of Neurobiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053, China[6]Beijing Parkcare Technology Co Ltd, No. 18, Xihuan South Road, Beijing Economic and Technological Development Zone, Beijing 100176, China[*1]Xuanwu Hospital, 45 Changchun Street, Xicheng District, Beijing 100053, China[*2]Dongfang Hospital, Beijing University of Chinese Medicine, No. 6 Fangxingyuan 1st Block, Fengtai District, Beijing, 100078, China
推荐引用方式(GB/T 7714)：
Zhang Xinning,Wang Sushi,Li Xuran,et al.Hemoglobin-binding alpha-synuclein levels in erythrocytes are elevated in patients with multiple system atrophy[J].NEUROSCIENCE LETTERS.2022,789:doi:10.1016/j.neulet.2022.136868.
APA：
Zhang, Xinning,Wang, Sushi,Li, Xuran,Li, Xin,Ran, Weizheng...&Chen, Zhigang.(2022).Hemoglobin-binding alpha-synuclein levels in erythrocytes are elevated in patients with multiple system atrophy.NEUROSCIENCE LETTERS,789,
MLA：
Zhang, Xinning,et al."Hemoglobin-binding alpha-synuclein levels in erythrocytes are elevated in patients with multiple system atrophy".NEUROSCIENCE LETTERS 789.(2022)
