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Biological small-calibre tissue engineered blood vessels developed by electrospinning and in-body tissue architecture

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机构： [1]Vascular Surgery Department, Xuanwu Hospital, Capital Medical University, 100053 Beijing, China [2]Department of Cardiovascular Surgery, Beijing Children’s Hospital, National Center for Children’s Health, Capital Medical University, 100045 Beijing, China

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There are no suitable methods to develop the small-calibre tissue-engineered blood vessels (TEBVs) that can be widely used in the clinic. In this study, we developed a new method that combines electrospinning and in-body tissue architecture(iBTA) to develop small-calibre TEBVs. Electrospinning imparted mechanical properties to the TEBVs, and the iBTA imparted biological properties to the TEBVs. The hybrid fibres of PLCL (poly(L-lactic-co-ε-caprolactone) and PU (Polyurethane) were obtained by electrospinning, and the fibre scaffolds were then implanted subcutaneously in the abdominal area of the rabbit (as an in vivo bioreactor). The biotubes were harvested after four weeks. The mechanical properties of the biotubes were most similar to those of the native rabbit aorta. Biotubes and the PLCL/PU vascular scaffolds were implanted into the rabbit carotid artery. The biotube exhibited a better patency rate and certain remodelling ability in the rabbit model, which indicated the potential use of this hybridization method to develop small-calibre TEBVs. Sketch map of developing the biotube. The vascular scaffolds were prepared by electrospinning (A). Silicone tube was used as the core, and the vascular scaffold was used as the shell (B). The vascular scaffold and silicone tube were implanted subcutaneously in the abdominal area of the rabbit (C). The biotube was extruded from the silicone tube after 4 weeks ofembedding (D). The biotube was implanted for the rabbit carotid artery (E).© 2022. The Author(s).

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出版当年[2021]版：

大类 | 3 区工程技术

小类 | 3 区工程：生物医学 3 区材料科学：生物材料

最新[2023]版：

大类 | 3 区医学

小类 | 3 区工程：生物医学 4 区材料科学：生物材料

JCR分区：

出版当年[2020]版：

Q2 ENGINEERING, BIOMEDICAL Q3 MATERIALS SCIENCE, BIOMATERIALS

最新[2023]版：

Q2 ENGINEERING, BIOMEDICAL Q2 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 4.2 最新[2023版] 4.2 最新五年平均 3.896 出版当年[2020版] 3.444 出版当年五年平均 2.489 出版前一年[2019版] 4.727 出版后一年[2021版]

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第一作者机构： [1]Vascular Surgery Department, Xuanwu Hospital, Capital Medical University, 100053 Beijing, China

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