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In-Stent Stenosis After Pipeline Embolization Device in Intracranial Aneurysms: Incidence, Predictors, and Clinical Outcomes

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机构: [1]Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, People's Republic of China. [2]Department of Interventional Neuroradiology, Beijing TianTan Hospital, Capital Medical University, Beijing, People's Republic of China. [3]Department of Neurosurgery, Changhai Hospital, Shanghai, People's Republic of China. [4]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, People's Republic of China. [5]Department of Neurosurgery, Zhengzhou University People's Hospital, Zhengzhou, People's Republic of China. [6]Department of Neurosurgery, Shanghai Donglei Brain Hospital, Shanghai, People's Republic of China. [7]Department of Neurosurgery, Peking University International Hospital, Beijing, People's Republic of China. [8]Department of Neurosurgery, Xinjiang Medical University Affiliated First Hospital, Urumqi, People's Republic of China. [9]Department of Neurosurgery, Qilu Hospital, Shandong University, Jinan, People's Republic of China. [10]Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China. [11]Department of Neurosurgery, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China. [12]Department of Neurosurgery, Beijing ChaoYang Hospital, Capital Medical University, Beijing, People's Republic of China. [13]Department of Neurosurgery, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, People's Republic of China. [14]Department of Neurosurgery, Nanchang University Second Affiliated Hospital, Nanchang, People's Republic of China. [15]Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China. [16]Department of Intervention Neuroradiology, Zhengzhou University First Affiliated Hospital, Zhengzhou, People's Republic of China.
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In-stent stenosis (ISS) is a delayed complication that can occur after pipeline embolization device use when treating intracranial aneurysms (IAs).To assess the incidence, predictors, and outcomes of ISS.This was a retrospective, multicenter, observational study. All patient data were collected from a PLUS registry study. We collected data from patients with IA who completed digital subtraction angiography at follow-up and divided patients into "non-ISS," "mild ISS," or "severe ISS" groups. Multivariate logistic regression analysis was conducted to determine predictors of ISS.A total of 1171 consecutive patients with 1322 IAs participated in this study. Angiographic follow-up was available for 662 patients with 728 IAs, and the mean follow-up time was 9 months. ISS was detected in 73 cases (10.03%), including 61 mild ISS cases and 12 severe ISS cases. Univariate and multivariable analysis demonstrated that current smoking history (mild ISS: OR 2.15, 95% CI 1.122-4.118, P = .021; severe ISS: OR 5.858, 95% CI 1.186-28.93, P = .030) and cerebral atherosclerosis (mild ISS: OR 5.694, 95% CI 3.193-10.15, P = .001; severe ISS: OR 6.103, 95% CI 1.384-26.91, P = .017) were independent predictors of ISS. Compared with the other groups, the severe ISS group had higher rate of ischemic stroke (33.3%).ISS occurs in approximately 10.03% of cases at a mean follow-up of 9 months. Statistically, current smoking history and cerebral atherosclerosis are the main predictors of ISS. Severe ISS may be associated with higher risk of neurological ischemic events in patients with IA after pipeline embolization device implantation.Copyright © Congress of Neurological Surgeons 2022. All rights reserved.

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出版当年[2021]版:
大类 | 2 区 医学
小类 | 2 区 临床神经病学 2 区 外科
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 临床神经病学 2 区 外科
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出版当年[2020]版:
Q1 SURGERY Q2 CLINICAL NEUROLOGY
最新[2023]版:
Q1 CLINICAL NEUROLOGY Q1 SURGERY

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第一作者机构: [1]Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, People's Republic of China. [2]Department of Interventional Neuroradiology, Beijing TianTan Hospital, Capital Medical University, Beijing, People's Republic of China.
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