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Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis

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机构： [1]Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China. [2]Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325027, China. [3]Department of Orthopedics, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Xicheng, Beijing 100053, People’s Republic of China. [4]The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China [5]Department of Cardiology, Zhejiang Yuhuan People’s Hospital, Yuhuan 317600, Zhejiang, China. [6]Tianjin Key Laboratory of Spine and Spinal Cord, Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin 300050, China.

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Stimulator of interferons genes (STING), which is crucial for the secretion of type I interferons and proinflammatory cytokines in response to cytosolic nucleic acids, plays a key role in the innate immune system. Studies have revealed the participation of the STING pathway in unregulated inflammatory processes, traumatic brain injury (TBI), spinal cord injury (SCI), subarachnoid haemorrhage (SAH) and hypoxic-ischaemic encephalopathy (HIE). STING signalling is markedly increased in CNS injury, and STING agonists might facilitate the pathogenesis of CNS injury. However, the effects of STING-regulated signalling activation in CNS injury are not well understood. Aberrant activation of STING increases inflammatory events, type I interferon responses, and cell death. cGAS is the primary pathway that induces STING activation. Herein, we provide a comprehensive review of the latest findings related to STING signalling and the cGAS-STING pathway and highlight the control mechanisms and their functions in CNS injury. Furthermore, we summarize and explore the most recent advances toward obtaining an understanding of the involvement of STING signalling in programmed cell death (autophagy, necroptosis, ferroptosis and pyroptosis) during CNS injury. We also review potential therapeutic agents that are capable of regulating the cGAS-STING signalling pathway, which facilitates our understanding of cGAS-STING signalling functions in CNS injury and the potential value of this signalling pathway as a treatment target.© 2022. The Author(s).

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出版当年[2021]版：

大类 | 1 区

医学

小类 | 1 区免疫学 1 区神经科学

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区免疫学 1 区神经科学

JCR分区：

出版当年[2020]版：

Q1 IMMUNOLOGY Q1 NEUROSCIENCES

最新[2023]版：

Q1 NEUROSCIENCES Q1 IMMUNOLOGY

影响因子： 9.3 最新[2023版] 9.8 最新五年平均 8.322 出版当年[2020版] 8.218 出版当年五年平均 5.793 出版前一年[2019版] 9.589 出版后一年[2021版]

第一作者：

第一作者机构： [1]Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China. [2]Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325027, China. [3]Department of Orthopedics, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Xicheng, Beijing 100053, People’s Republic of China.

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通讯作者：

通讯机构： [1]Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China. [2]Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325027, China.

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Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis $(function () { $("[data-toggle='tooltip']").tooltip(); });

文献详情

Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis