This study aimed to establish a mobile health application (APP) to timely diagnose and treat the post-discharge hardware-related infections, and to prevent the removal of complete hardware or implantable pulse generator (IPG).We conducted a retrospective and historical controlled study of all patients who had undergone initial hardware implantation at a single center. All participants were aggregated into two groups, group A (between June 2005 and June 2014) and group B (between July 2014 and May 2020). In group B, Post Discharge patient Aide (PDA) solution were applied for wounds monitoring. Both groups were received regular clinical follow-up. Cases and range of hardware-related infections were compared.There was no significant difference in infection rate between groups (1.8% vs. 1.4%, P=0.413). After application of PDA, the proportion of patients with early interventions had increased significantly in group B compared with group A (83.3% vs. 20.0%, P<0.001). Patients with IPG infection at time of interventions in group B was significantly lower than that in group A (8.3% vs. 60.0%, P<0.001). The IPG preservation rate in group B was significantly higher than that in group A (75.0% vs. 16.0%, P<0.001).Mobile health APP provides an efficient way to early diagnose and treat the hardware-related infection and prevent hardware removal. Information of wounds healing should be transmitted to the surgery team in a convenient and fast way to prevent infection spreading, which help to prevent the IPG abandoned.Copyright © 2022 Elsevier Inc. All rights reserved.