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PEDIATRIC CEREBRAL MENINGIOMA: A SINGLE CENTER STUDY WITH 10 CHILDREN NOT ASSOCIATED WITH NEUROFIBROMATOSIS TYPE 2 AND LITERATURE REVIEW

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机构: [1]Capital Med Univ, Xuanwu Hosp, China Int Neurosci Inst China INI, Dept Neurosurg, Beijing, Peoples R China [2]Capital Med Univ, China Int Neurosci Inst China INI, Dept Neurosurg, Beijing 100053, Peoples R China
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关键词: Pediatric meningiomas tumor atypical

摘要:
Introduction: Pediatric meningiomas are rare tumors, they differ from their adult counterparts by their atypicality of location, higher rates of malignant change, male preponderance, recurrence and sometimes their association with neurofibromatosis. This case series analyzes the clinical behavior, pathological presentation, location and its association with Neurofibromatosis type 2 (NF2). Methods: This case series consists of pediatric patients between the ages of 4 and 16 years who were hospitalized in the neurosurgical department of our hospital from 2012 to 2021 with different neurological symptoms and a literature view using PubMed/Medline database. Results: 60% of the patients were males whiles 40% were females. The most common neurological manifestation were signs of increased intracranial pressure. NF2 was absent in all patients. The predominant histopathology subtype is Atypical and WHO Grade II representing 30% and 40% respectively. Conclusion: This study supports the relationship between NF2 and pediatric cerebral meningioma but at a lower concomitant rate from 0 to 13% taking into consideration our original data and the literature review, contrasting some reported cases which suggest rates as high as 33%, 50% and 100% in a very small number of patients. Gross total resection (GTR) without post operatory radiation therapy for non-malignant and non NF2 associated pediatric meningioma (PM) proved to be a sufficient and a good treatment option.

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出版当年[2022]版:
大类 | 4 区 医学
小类 | 4 区 外科 4 区 临床神经病学 4 区 儿科
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 儿科 4 区 外科
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出版当年[2021]版:
Q4 CLINICAL NEUROLOGY Q4 PEDIATRICS Q4 SURGERY
最新[2023]版:
Q3 SURGERY Q3 PEDIATRICS Q4 CLINICAL NEUROLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

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第一作者机构: [1]Capital Med Univ, Xuanwu Hosp, China Int Neurosci Inst China INI, Dept Neurosurg, Beijing, Peoples R China
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