机构：[1]Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, P. R. China.[2]School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing, 101400, P. R. China.[3]Center on Nanoenergy Research, Guangxi University, Nanning, 530004, P. R. China.[4]Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 101400, P. R. China.内科系统老年医学科首都医科大学宣武医院[5]School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, 30332-0245, USA.
Gas therapy has been emerging technology for improving cancer therapy with high efficiency and low side effects. However, due to the existence of the gatekeeper of blood - brain barrier (BBB) and limited availability of current drug delivery systems, there still have no reports on gas therapy for intracranial neuroglioma. Herein, we report an integrated, self-powered and wirelessly-controlled gas therapy system composed of a self-powered triboelectric nanogenerator (TENG) and implantable nitric oxide (NO) releasing device for intracranial neuroglioma therapy. In the system, the patient self-driven TENG converts the mechanical energy of body movements into electricity as a sustainable and self-controlled power source. When delivering the energy to lighten LED light in the implantable NO releasing device via wireless control, the encapsulated NO donor s-nitrosoglutathione (GSNO) can generate NO gas to locally kill the glioma cells. We verify the efficacy of the proof-of-concept system in subcutaneous 4T1 breast cancer model in mice and intracranial glioblastoma multiforme in rats. This self-powered gas therapy system has great potential to be an effective adjuvant treatment modality to inhibit tumor growth, relapse, and invasion via teletherapy. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
第一作者机构：[1]Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, P. R. China.[2]School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing, 101400, P. R. China.
通讯作者：
推荐引用方式(GB/T 7714)：
Yao Shuncheng,Zheng Minjia,Wang Zhuo,et al.Self-powered, Implantable, and Wirelessly-Controlled NO Generation System for Intracranial Neuroglioma Therapy[J].ADVANCED MATERIALS.2022,34(50):doi:10.1002/adma.202205881.
APA：
Yao Shuncheng,Zheng Minjia,Wang Zhuo,Zhao Yunchao,Wang Shaobo...&Li Linlin.(2022).Self-powered, Implantable, and Wirelessly-Controlled NO Generation System for Intracranial Neuroglioma Therapy.ADVANCED MATERIALS,34,(50)
MLA：
Yao Shuncheng,et al."Self-powered, Implantable, and Wirelessly-Controlled NO Generation System for Intracranial Neuroglioma Therapy".ADVANCED MATERIALS 34..50(2022)
材料科学