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Regulatory pattern of abnormal promoter CpG island methylation in the glioblastoma multiforme classification

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收录情况： ◇ SCIE

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机构： [1]School of Biomedical Engineering, Capital Medical University, Beijing, China. [2]Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, China. [3]Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.

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Glioblastoma (GBM) is characterized by extensive genetic and phenotypic heterogeneity. However, it remains unexplored primarily how CpG island methylation abnormalities in promoter mediate glioblastoma typing. First, we presented a multi-omics scale map between glioblastoma sample clusters constructed based on promoter CpG island (PCGI) methylation-driven genes, using datasets including methylation profiles, expression profiles, and single-cell sequencing data from multiple highly annotated public clinical cohorts. Second, we identified differences in the tumor microenvironment between the two glioblastoma sample clusters and resolved key signaling pathways between cell clusters at the single-cell level based on comprehensive comparative analyses to investigate the reasons for survival differences between two of these clusters. Finally, we developed a diagnostic map and a prediction model for glioblastoma, and compared theoretical differences of drug sensitivity between two glioblastoma sample clusters. In summary, this study established a classification system for dissecting promoter CpG island methylation heterogeneity in glioblastoma and provides a new perspective for the diagnosis and treatment of glioblastoma.Copyright © 2022 Wang, Zhao, Wang, Zhao, Liang, Wang and Li.

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出版当年[2021]版：

大类 | 3 区生物学

小类 | 3 区遗传学

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区遗传学

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出版当年[2020]版：

Q2 GENETICS & HEREDITY

最新[2023]版：

Q2 GENETICS & HEREDITY

影响因子： 2.8 最新[2023版] 3.3 最新五年平均 4.599 出版当年[2020版] 4.888 出版当年五年平均 3.26 出版前一年[2019版] 4.772 出版后一年[2021版]

第一作者：

第一作者机构： [1]School of Biomedical Engineering, Capital Medical University, Beijing, China. [2]Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, China.

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通讯作者：

通讯机构： [1]School of Biomedical Engineering, Capital Medical University, Beijing, China. [2]Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing, China.

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