Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a promising palliative option for patients with refractory epilepsy. However, crucial questions remain unanswered: Which patients are the optimal candidates? How, where, and when to stimulate the STN? And what is the mechanism of STN-DBS action on epilepsy? Thus, we reviewed the clinical evidence on the antiepileptic effects of STN-DBS and its possible mechanisms on drug-resistant epilepsy, its safety, and the factors influencing stimulation outcomes. This information may guide clinical decision-making. In addition, based on the current knowledge on the effect of STN-DBS on epilepsy, we suggest research that needs to be carried out in the future.
基金：
Beijing Municipal Education Commission -Natural Science Foundation [KZ202110025036]; Science and Technology Innovation Project [2021ZD0201605]
第一作者机构：[1]Capital Med Univ, Xuanwu Hosp, Beijing Inst Funct Neurosurg, Dept Funct Neurosurg, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Xuanwu Hosp, Beijing Inst Funct Neurosurg, Dept Funct Neurosurg, Beijing, Peoples R China[2]Capital Med Univ, Xuanwu Hosp, Beijing Key Lab Neuromodulat, Dept Neurol,Comprehens Epilepsy Ctr Beijing, Beijing, Peoples R China[*1]Department of Functional Neurosurgery, Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.[*2]Department of Neurology, Comprehensive Epilepsy Center of Beijing, Beijing Key Laboratory of Neuromodulation, Xuanwu Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Yan Hao,Ren Liankun,Yu Tao.Deep brain stimulation of the subthalamic nucleus for epilepsy[J].ACTA NEUROLOGICA SCANDINAVICA.2022,146(6):798-804.doi:10.1111/ane.13707.
APA：
Yan, Hao,Ren, Liankun&Yu, Tao.(2022).Deep brain stimulation of the subthalamic nucleus for epilepsy.ACTA NEUROLOGICA SCANDINAVICA,146,(6)
MLA：
Yan, Hao,et al."Deep brain stimulation of the subthalamic nucleus for epilepsy".ACTA NEUROLOGICA SCANDINAVICA 146..6(2022):798-804
