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Intracranial direct electrical mapping reveals the functional architecture of the human basal ganglia

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机构： [1]Department of Neurology, Xuanwu Hospital, Clinical Center for Epilepsy, Capital Medical University, Beijing, China [2]National Center for NeurologicalDisorders, Beijing, China [3]Department of Functional Neurosurgery, Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Clinical Center forEpilepsy, Capital Medical University, Beijing, China [4]Department of Pharmacy Phase I Clinical Trial Center, Xuanwu Hospital, Clinical Center for Epilepsy,Capital Medical University, Beijing, China [5]Department of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Institute forTranslational Brain Research, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China [6]School of Engineering Medicine, BeihangUniversity, Beijing, China [7]Department of Neurosurgery, Xuanwu Hospital, Clinical Center for Epilepsy, Capital Medical University, Beijing, China [8]ChineseInstitute for Brain Research, Beijing, China

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The basal ganglia play a key role in integrating a variety of human behaviors through the cortico-basal ganglia-thalamo-cortical loops. Accordingly, basal ganglia disturbances are implicated in a broad range of debilitating neuropsychiatric disorders. Despite accumulating knowledge of the basal ganglia functional organization, the neural substrates and circuitry subserving functions have not been directly mapped in humans. By direct electrical stimulation of distinct basal ganglia regions in 35 refractory epilepsy patients undergoing stereoelectroencephalography recordings, we here offer currently the most complete overview of basal ganglia functional characterization, extending not only to the expected sensorimotor responses, but also to vestibular sensations, autonomic responses, cognitive and multimodal effects. Specifically, some locations identified responses weren't predicted by the model derived from large-scale meta-analyses. Our work may mark an important step toward understanding the functional architecture of the human basal ganglia and provide mechanistic explanations of non-motor symptoms in brain circuit disorders.© 2022. The Author(s).

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出版当年[2021]版：

大类 | 2 区

生物学

小类 | 1 区生物学

最新[2025]版：

大类 | 1 区

生物学

小类 | 1 区生物学

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出版当年[2020]版：

Q1 BIOLOGY

最新[2024]版：

Q1 BIOLOGY

影响因子： 5.1 最新[2024版] 5.8 最新五年平均 6.268 出版当年[2020版] 6.268 出版当年五年平均 4.165 出版前一年[2019版] 6.548 出版后一年[2021版]

第一作者：

第一作者机构： [1]Department of Neurology, Xuanwu Hospital, Clinical Center for Epilepsy, Capital Medical University, Beijing, China [2]National Center for NeurologicalDisorders, Beijing, China

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通讯作者：

通讯机构： [1]Department of Neurology, Xuanwu Hospital, Clinical Center for Epilepsy, Capital Medical University, Beijing, China [2]National Center for NeurologicalDisorders, Beijing, China [3]Department of Functional Neurosurgery, Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Clinical Center forEpilepsy, Capital Medical University, Beijing, China [7]Department of Neurosurgery, Xuanwu Hospital, Clinical Center for Epilepsy, Capital Medical University, Beijing, China [8]ChineseInstitute for Brain Research, Beijing, China

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