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A stem cell aging framework, from mechanisms to interventions

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Liu Beibei[1] * ; Qu Jing[2,4,5] ; Zhang Weiqi[1] ; Izpisua Belmonte Juan Carlos[6] ; Liu Guang-Hui[3,4,5,7] ;
机构： [1]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China [2]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [4]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [5]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [6]Altos Labs, Inc., San Diego, CA, USA [7]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China
出处：
DOI： 10.1016/j.celrep.2022.111451
ISSN：

摘要：
Stem cells play central roles in tissue development, homeostasis, and regeneration. Decades of scientific research have uncovered processes of stem cell decline in tissue and organismal aging, and more recently, pioneering technologies permit the dissection of its underlying mechanisms and inform therapeutic development for aging and aging-associated disorders. In this review, we elucidate aging-related features across different somatic stem cell types, with a specific focus on epigenetic changes, loss of protein homeostasis, and systemic influencing factors, including chronic inflammation, circadian rhythm dysregulation, and metabolic disorder. Our survey of organismal stem cell aging summarizes its underlying biological implications, points to potential biomarkers of stem cell aging, and discusses stem cell-based therapeutic strategies with the potential for promoting healthy aging and combating aging and age-related diseases.Copyright © 2022. Published by Elsevier Inc.

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
最新[2023]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
JCR分区：
出版当年[2020]版：
Q1 CELL BIOLOGY
最新[2023]版：
Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China
通讯作者：
通讯机构： [2]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [4]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [5]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [7]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Liu Beibei,Qu Jing,Zhang Weiqi,et al.A stem cell aging framework, from mechanisms to interventions[J].CELL REPORTS.2022,41(3):doi:10.1016/j.celrep.2022.111451.
APA：
Liu Beibei,Qu Jing,Zhang Weiqi,Izpisua Belmonte Juan Carlos&Liu Guang-Hui.(2022).A stem cell aging framework, from mechanisms to interventions.CELL REPORTS,41,(3)
MLA：
Liu Beibei,et al."A stem cell aging framework, from mechanisms to interventions".CELL REPORTS 41..3(2022)

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