机构：[1]Department of Pulmonary and Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.首都医科大学宣武医院[2]Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China.首都医科大学宣武医院[3]Department of Cell Biology and Genetics, School of Basic Medicine, Shenzhen University Health Science, Shenzhen, China.深圳市康宁医院深圳医学信息中心[4]Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China.
Obstructive sleep apnea (OSA) is a multi-component disorder, which has many comorbidities, including cognitive impairment. Although its potential risk factors were unknown, they could affect the patient's quality of life and long-term prognosis.The purpose of this study was to investigate the application of urinary Alzheimer's disease-associated neurofilament protein (AD7c-NTP) levels in the assessment of cognitive impairment in OSA patients, and to analyze the predictive value of potential high-risk factors on cognitive impairment in OSA patients.138 young and middle-aged adults were recruited and underwent overnight polysomnographic recording, Montreal Cognitive Assessment (MoCA), and urinary AD7c-NTP test. AD7c-NTP and other factors were further applied as biomarkers to develop a cognition risk prediction model.Compared with the control, OSA patients showed significantly lower MoCA scores and higher urinary AD7c-NTP concentrations, while the severe OSA group appeared more significant. The urinary AD7c-NTP level of the OSA cognitive impairment group was higher than that of the non-cognitive impairment group. The results of regression analysis showed that urinary AD7c-NTP level was an independent predictor of cognitive impairment in OSA patients. Based on urinary AD7c-NTP levels and other selected factors, a multimodal prediction model for assessing the risk of cognitive impairment in OSA patients was initially established.The increased urinary AD7c-NTP level could be used as a relevant peripheral biomarker of cognitive impairment in OSA patients. A model using urinary AD7c-NTP combined with other factors was developed and could accurately assess the cognition risk of OSA patients.
第一作者机构：[1]Department of Pulmonary and Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pulmonary and Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.[2]Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China.[3]Department of Cell Biology and Genetics, School of Basic Medicine, Shenzhen University Health Science, Shenzhen, China.[*1]Department of Pulmonary and Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China[*2]Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Guo Yumiao,Kang Meimei,Hui Xinjie,et al.The Association Between Cognition of Obstructive Sleep Apnea Patients and Urinary AD7c-NTP Level: Investigation and Application[J].JOURNAL OF ALZHEIMERS DISEASE.2022,90(3):1215-1231.doi:10.3233/JAD-220451.
APA：
Guo Yumiao,Kang Meimei,Hui Xinjie,Fan Xiaojun,Zhang Lianguo...&Nie Xiuhong.(2022).The Association Between Cognition of Obstructive Sleep Apnea Patients and Urinary AD7c-NTP Level: Investigation and Application.JOURNAL OF ALZHEIMERS DISEASE,90,(3)
MLA：
Guo Yumiao,et al."The Association Between Cognition of Obstructive Sleep Apnea Patients and Urinary AD7c-NTP Level: Investigation and Application".JOURNAL OF ALZHEIMERS DISEASE 90..3(2022):1215-1231
