个人科研网厅 | | 帮助
首都医科大学宣武医院知识库
高级检索
当前位置： 首页 > 详情页

Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Jovin Tudor G[1,33] * ; Li Chuanhui[2,3] * ; Wu Longfei[2] ; Wu Chuanjie[2] ; Chen Jian[1] ; Jiang Changchun[8] ; Shi Zhonghua[9] ; Gao Zongen[10] ; Song Cunfeng[11] ; Chen Wenhuo[12] ; Peng Ya[13] ; Yao Chen[7] ; Wei Ming[14] ; Li Tong[17] ; Wei Liping[18] ; Xiao Guodong[19] ; Yang Hua[20] ; Ren Ming[21] ; Duan Jiangang[4] ; Liu Xinfeng[22] ; Yang Qingwu[24] ; Liu Yuxiu[23] ; Zhu Qingfeng[25] ; Shi Wanchao[15] ; Zhu Qiyi[26] ; Li Xiaobo[27] ; Guo Zaiyu[16] ; Yang Qi[6] ; Hou Chengbei[5] ; Zhao Wenbo[2] ; Ma Qingfeng[2] ; Zhang Yunzhou[2] ; Jiao Liqun[1] ; Zhang Hongqi[1] ; Liebeskind David S[34] ; Liang Hui[28] ; Jadhav Ashutosh P[35] ; Wen Changming[29] ; Brown Scott[36] ; Zhu Liangfu[30] ; Ye Huawei[31] ; Ribo Marc[37] ; Chang Mingze[32] ; Song Haiqing[2] ; Chen Jun[38] ; Ji Xunming[1,*1] ; for the BAOCHE Investigators[1] ;
机构： [1]Department of Neurosurgery,Xuanwu Hospital [2]Department of Neurology,Xuanwu Hospital [3]Stroke Center,Xuanwu Hospital [4]Department of Emergency Medicine,Xuanwu Hospital [5]Center for Evidence-Based Medicine,Xuanwu Hospital [6]Department of Radiology, Beijing Chaoyang Hospital,Capital Medical University, [7]Peking University Clinical Research Institute, Peking University First Hospital,Beijing [8]Department of Neurology, Baotou Central Hospital of Inner Mongolia Medical University,Baotou [9]Department of Neurosurgery, the 904th Hospital of the People’s Liberation Army (PLA), Wuxi [10]the Department of Neurology, Central Hospital of Shengli Oil Field, Dongying [11]Department of Neurology, Liaocheng Third People’s Hospital, Liaocheng [12]Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou [13]Department of Neurosurgery, the First People’s Hospital of Changzhou, Changzhou [14]Department of Neurosurgery, Tianjin Huanhu Hospital [15]Department of Neurosurgery, Binhai Hospital of Beijing University [16]Department of Neurosurgery, Tianjin Teda Hospital,Tianjin, [17]Department of Neurology, Nanning Second People’s Hospital, Nanning [18]Department of Radiology, Luoyang Central Hospital of Zhengzhou University, Luoyang [19]Department of Neurology and the Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University, Suzhou [20]Department of Neurosurgery, Affiliated Hospital of Guizhou Medical University, Guiyang [21]Department of Neurology, Shanghai Blue Cross Hospital, Shanghai [22]Department of Neurology,Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing [23]Department of Critical Care Medicine, Data and Statistics Division,Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing [24]Department of Neurology, Xinqiao Hospital and Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing [25]Department of Neurosurgery, 985th Hospital of the PLA, Taiyuan [26]Department of Neurology, Linyi People’s Hospital, Linyi [27]Department of Neurology, Subei People’s Hospital, Yangzhou [28]Department of Neurology, Yantaishan Hospital of Shandong First Medical University, Yantai [29]Department of Neurology, Nanyang Central Hospital of Xinxiang Medical University, Nanyang [30]Cerebrovascular Center, Henan Provincial People’s Hospital, Zhengzhou [31]Department of Neurosurgery, Hospital of Baoan People’s Hospital, Shenzhen [32]Department of Neurology, Xi’an No.3 Hospital, Xi’an (M.C.), — all in China [33]Cooper University Healthcare and Cooper Medical School of Rowan University,Camden, NJ [34]the Department of Neurology and Comprehensive Stroke Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles [35]the Department of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ [36]Altair Biostatistics, Mooresville, NC [37]Stroke Unit, Hospital Vall d’Hebrón, Barcelona [38]Department of Neurology, Pittsburgh Institute of Brain Disorder and Recovery, University of Pittsburgh Medical Center and Veterans Affairs Pittsburgh Health Care System, Geriatric Research Education and Clinical Center, Pittsburgh
出处：
DOI： 10.1056/NEJMoa2207576
ISSN：

摘要：
The effects and risks of endovascular thrombectomy 6 to 24 hours after stroke onset due to basilar-artery occlusion have not been extensively studied.In a trial conducted over a 5-year period in China, we randomly assigned, in a 1:1 ratio, patients with basilar-artery stroke who presented between 6 to 24 hours after symptom onset to receive either medical therapy plus thrombectomy or medical therapy only (control). The original primary outcome, a score of 0 to 4 on the modified Rankin scale (range, 0 to 6, with a score of 0 indicating no disability, 4 moderately severe disability, and 6 death) at 90 days, was changed to a good functional status (a modified Rankin scale score of 0 to 3, with a score of 3 indicating moderate disability). Primary safety outcomes were symptomatic intracranial hemorrhage at 24 hours and 90-day mortality.A total of 217 patients (110 in the thrombectomy group and 107 in the control group) were included in the analysis; randomization occurred at a median of 663 minutes after symptom onset. Enrollment was halted at a prespecified interim analysis because of the superiority of thrombectomy. Thrombolysis was used in 14% of the patients in the thrombectomy group and in 21% of those in the control group. A modified Rankin scale score of 0 to 3 (primary outcome) occurred in 51 patients (46%) in the thrombectomy group and in 26 (24%) in the control group (adjusted rate ratio, 1.81; 95% confidence interval [CI], 1.26 to 2.60; P<0.001). The results for the original primary outcome of a modified Rankin scale score of 0 to 4 were 55% and 43%, respectively (adjusted rate ratio, 1.21; 95% CI, 0.95 to 1.54). Symptomatic intracranial hemorrhage occurred in 6 of 102 patients (6%) in the thrombectomy group and in 1 of 88 (1%) in the control group (risk ratio, 5.18; 95% CI, 0.64 to 42.18). Mortality at 90 days was 31% in the thrombectomy group and 42% in the control group (adjusted risk ratio, 0.75; 95% CI, 0.54 to 1.04). Procedural complications occurred in 11% of the patients who underwent thrombectomy.Among patients with stroke due to basilar-artery occlusion who presented 6 to 24 hours after symptom onset, thrombectomy led to a higher percentage with good functional status at 90 days than medical therapy but was associated with procedural complications and more cerebral hemorrhages. (Funded by the Chinese National Ministry of Science and Technology; BAOCHE ClinicalTrials.gov number, NCT02737189.).Copyright © 2022 Massachusetts Medical Society.

语种：
外文
高被引：
热点：
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 1 区 医学
小类 | 1 区 医学：内科
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 医学：内科
JCR分区：
出版当年[2020]版：
Q1 MEDICINE, GENERAL & INTERNAL
最新[2023]版：
Q1 MEDICINE, GENERAL & INTERNAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Department of Neurosurgery,Xuanwu Hospital [33]Cooper University Healthcare and Cooper Medical School of Rowan University,Camden, NJ
共同第一作者：
通讯作者：
通讯机构： [1]Department of Neurosurgery,Xuanwu Hospital [*1]Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, 45 Changchun St., Xi Cheng District, Beijing, 100053, China.
推荐引用方式(GB/T 7714)：
Jovin Tudor G,Li Chuanhui,Wu Longfei,et al.Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion[J].NEW ENGLAND JOURNAL OF MEDICINE.2022,387(15):1373-1384.doi:10.1056/NEJMoa2207576.
APA：
Jovin Tudor G,Li Chuanhui,Wu Longfei,Wu Chuanjie,Chen Jian...&for the BAOCHE Investigators.(2022).Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion.NEW ENGLAND JOURNAL OF MEDICINE,387,(15)
MLA：
Jovin Tudor G,et al."Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion".NEW ENGLAND JOURNAL OF MEDICINE 387..15(2022):1373-1384

资源点击量：16409 今日访问量：0 总访问量：869 更新日期：2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持：重庆聚合科技有限公司 地址：北京市西城区长椿街45号宣武医院