机构：[1]Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.首都医科大学附属天坛医院[2]China National Clinical Research Center for Neurological Diseases, Beijing, China.[3]Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, Zhejiang, China.[4]Research Center for Healthcare Data Science, Zhejiang Lab, Hangzhou, Zhejiang, China.[5]Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.[6]Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.内科系统老年医学科首都医科大学宣武医院[7]Parkinson's Disease Center, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
The utility of imaging methods to detect iron content in the substantia nigra pars compacta (SNc) and free water imaging in the posterior substantia nigra (pSN) has the potential to be imaging markers for the detection of Parkinson's disease (PD).This study aimed to compare the discriminative power of above methods, and whether the combination can improve the diagnostic potential of PD.Quantitative susceptibility mapping (QSM) and diffusion-weighted data were obtained from 41 healthy controls (HC), 37 patients with idiopathic REM sleep behavior disorder (RBD), and 65 patients with PD. Mean QSM values of bilateral SNc and mean isotropic volume fraction (Viso) values of bilateral pSN (mean QSM|Viso values of bilateral SNc|pSN) were separately calculated and compared among the groups.Mean QSM|Viso values of bilateral SNc|pSN were significantly higher for RBD and PD patients compared to HC and were significantly higher in PD patients than in RBD patients. The power of the mean QSM|Viso values of bilateral SNc|pSN and combined mean QSM and Viso values was 0.873, 0.870, and 0.961 in discriminating PD and HC, 0.779, 0.719, and 0.864 in discriminating RBD from HC, 0.634, 0.636, and 0.689 in discriminating PD and RBD patients.QSM and free water imaging have similar discriminative power in the detection of prodromal and clinical PD, while combination of these two methods increases discriminative power. Our findings suggest that the combination of QSM and free water imaging has the potential to become an imaging marker for the diagnosis of PD.
基金：
National Key R&D Program of China 509
(2020AAA0109502) and the National Natural Sci- 510
ence Foundation of China (no. 81871428, 82071423 511
and 82102139), China Postdoctoral Science Founda- 512
tion (2020TQ0296 and 2021M692961).
第一作者机构：[1]Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.[2]China National Clinical Research Center for Neurological Diseases, Beijing, China.
共同第一作者：
通讯作者：
通讯机构：[1]Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.[2]China National Clinical Research Center for Neurological Diseases, Beijing, China.[3]Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, Zhejiang, China.[7]Parkinson's Disease Center, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.[*1]Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 100070, Beijing, China[*2]College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
推荐引用方式(GB/T 7714)：
Zhang Dongling,Yao Junye,Sun Junyan,et al.Quantitative Susceptibility Mapping and Free Water Imaging of Substantia Nigra in Parkinson's Disease[J].JOURNAL OF PARKINSONS DISEASE.2022,12(8):2469-2478.doi:10.3233/JPD-223499.
APA：
Zhang Dongling,Yao Junye,Sun Junyan,Tong Qiqi,Zhu Silei...&Wu Tao.(2022).Quantitative Susceptibility Mapping and Free Water Imaging of Substantia Nigra in Parkinson's Disease.JOURNAL OF PARKINSONS DISEASE,12,(8)
MLA：
Zhang Dongling,et al."Quantitative Susceptibility Mapping and Free Water Imaging of Substantia Nigra in Parkinson's Disease".JOURNAL OF PARKINSONS DISEASE 12..8(2022):2469-2478
