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Spatial metabolomics identifies lipid profiles of human carotid atherosclerosis

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机构： [1]Department of Stroke Center, Central Hospital Affiliated to Shandong First Medical University, China [2]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China [3]National Center for Occupational Safety and Health, NHC (National Center for Occupational Medicine of Coal Industry, NHC), Beijing, China [4]Department of Neurology, Liaocheng People’s Hospital, Liaocheng, Shandong Province, China [5]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China [6]Department of Neurosurgery, Liaocheng People’s Hospital, Liaocheng, Shandong Province, China [7]Zhongguancun Biological and Medical Big Data Center, Beijing, China [8]BaoFeng Key Laboratory of Genetics and Metabolism, Beijing, China [9]Zhongyuanborui Key Laborotory of Genetics and Metabolism, Guangdong-Macao In-depth Cooperation Zone in Hengqin, China [10]National Clinical Research Center for Geriatric Diseases, Beijing, China [11]China International Neuroscience Institute (China-INI), Beijing, 100053, China [12]Department of Interventional Neuroradiology, Xuanwu Hospital, Capital Medical University, Beijing, China

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关键词： Atherosclerosis Desorption electrospray ionization-mass spectrometry imaging Lipid profiles Spatial distribution Metabolism pathways

摘要：

Carotid atherosclerosis is an important cause of ischemic stroke. Lipids play a key role in the progression of atherosclerosis. To date, the spatial lipid profile of carotid atherosclerotic plaques related to histology has not been systematically investigated.Carotid atherosclerosis samples from 12 patients were obtained and classified into four classical pathological stages (preatheroma, atheroma, fibroatheroma and complicated lesion) by histological staining. Desorption electrospray ionization-mass spectrometry imaging (DESI-MSI) was used to investigate the lipid profile of carotid atherosclerosis, and correlated it with histological information. Bioinformatics technology was used to process MSI data among different pathological stages of atherosclerosis lesions.A total of 55 lipids (26 throughout cross-section regions [TCSRs], 13 in lipid-rich regions [LRRs], and 16 in collagen-rich regions [CRRs]) were initially identified in carotid plaque from one patient. Subsequently, 32 of 55 lipids (12 in TCSRs, eight in LRRs, and 12 in CRRs) were further screened in 11 patients. Pathway enrichment analysis showed that multiple metabolic pathways, such as fat digestion and absorption, cholesterol metabolism, lipid and atherosclerosis, were enriched in TCSRs; sphingolipid signaling pathway, necroptosis pathway were enriched in LRRs; and glycerophospholipid metabolism, ether lipid metabolism pathway were mainly enriched in CRRs.This study comprehensively showed the spatial lipid metabolism footprint in human carotid atherosclerotic plaques. The lipid profiles and related metabolism pathways in three regions of plaque with disease progression were different markedly, suggesting that the different metabolic mechanisms in these regions of carotid plaque may be critical in atherosclerosis progression.Copyright © 2022. Published by Elsevier B.V.

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出版当年[2022]版：

大类 | 2 区

医学

小类 | 2 区外周血管病 3 区心脏和心血管系统

最新[2023]版：

大类 | 2 区医学

小类 | 2 区外周血管病 3 区心脏和心血管系统

JCR分区：

出版当年[2021]版：

Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Q1 PERIPHERAL VASCULAR DISEASE

最新[2023]版：

Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Q1 PERIPHERAL VASCULAR DISEASE

影响因子： 4.9 最新[2023版] 5.3 最新五年平均 6.851 出版当年[2021版] 5.969 出版当年五年平均 5.162 出版前一年[2020版] 5.3 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Stroke Center, Central Hospital Affiliated to Shandong First Medical University, China [2]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China

通讯作者：

通讯机构： [2]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China [5]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China [10]National Clinical Research Center for Geriatric Diseases, Beijing, China [11]China International Neuroscience Institute (China-INI), Beijing, 100053, China [12]Department of Interventional Neuroradiology, Xuanwu Hospital, Capital Medical University, Beijing, China [*1]Department of Neurosurgery and Department of Interventional Neuroradiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, China. [*2]Department of Neurology, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Diseases, 45 Changchun Street, Beijing, China.

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Spatial metabolomics identifies lipid profiles of human carotid atherosclerosis

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