机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.神经科系统神经内科首都医科大学宣武医院[2]Beijing Key Laboratory of Neuromodulation, Beijing 100053, China.[3]Institute of sleep and consciousness disorders, Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China.
Mood disorders are associated with elevated inflammation, and the reduction of symptoms after multiple treatments is often accompanied by pro-inflammation restoration. A variety of neuromodulation techniques that regulate regional brain activities have been used to treat refractory mood disorders. However, their efficacy varies from person to person and lack reliable indicator. This review summarizes clinical and animal studies on inflammation in neural circuits related to anxiety and depression and the evidence that neuromodulation therapies regulate neuroinflammation in the treatment of neurological diseases. Neuromodulation therapies, including transcranial magnetic stimulation (TMS), transcranial electrical stimulation (TES), electroconvulsive therapy (ECT), photobiomodulation (PBM), transcranial ultrasound stimulation (TUS), deep brain stimulation (DBS), and vagus nerve stimulation (VNS), all have been reported to attenuate neuroinflammation and reduce the release of pro-inflammatory factors, which may be one of the reasons for mood improvement. This review provides a better understanding of the effective mechanism of neuromodulation therapies and indicates that inflammatory biomarkers may serve as a reference for the assessment of pathological conditions and treatment options in anxiety and depression.
基金：
We acknowledge the support of the Natural Science Foundation of Beijing (No.
7212048), the National Natural Science Foundation of China (No. 82071483), and the
National Key R&D Program(2021YFC2501403).
第一作者机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.[2]Beijing Key Laboratory of Neuromodulation, Beijing 100053, China.
通讯作者：
通讯机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.[2]Beijing Key Laboratory of Neuromodulation, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Guo Bingqi,Zhang Mengyao,Hao Wensi,et al.Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression[J].TRANSLATIONAL PSYCHIATRY.2023,13(1):doi:10.1038/s41398-022-02297-y.
APA：
Guo, Bingqi,Zhang, Mengyao,Hao, Wensi,Wang, Yuping,Zhang, Tingting&Liu, Chunyan.(2023).Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression.TRANSLATIONAL PSYCHIATRY,13,(1)
MLA：
Guo, Bingqi,et al."Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression".TRANSLATIONAL PSYCHIATRY 13..1(2023)
医学