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Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study

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机构： [1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China [2]Department of Geriatric, Fuxing Hospital, Capital Medical University, Beijing, China [3]Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University, Guangxi, China [4]Department of Neurology, The First Teaching Hospital of Jilin University, Jilin, China [5]Department of Neurology, The First Hospital of Kunming, Yunnan, China [6]Department of Psychiatry, Zhejiang Provincial People’s Hospital, Zhejiang, China [7]Department of Neurology, First Hospital of Shanxi Medical University, Shanxi, China [8]Department of Neurology, Shijiazhuang City Hospital, Hebei, China [9]Department of Neurology, the 960th Hospital of PLA, Shandong, China [10]Department of Neurology, Jiangxi Provincial People’s Hospital, Jiangxi, China [11]Department of Neurology, Handan Central Hospital, Hebei, China [12]Department of Neurology, Daqing Oilfield General Hospital, Heilongjiang, China [13]Department of Neurology, The First People’s Hospital of Yibin, Sichuan, China [14]Department of Neurology, The Third Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Gansu, China [15]Department of Neurology, Dongguan People’s Hospital, Guangdong, China [16]Department of Psychiatry, Beijing Geriatric Hospital, Beijing, China [17]Department of Neurology, Beijing Anding Hospital, Capital Medical University, Beijing, China [18]Department of Neurology, Beijing Jishuitan Hospital, Beijing, China [19]Department of Neurology, Baotou Central Hospital, Inner Mongolia, China [20]Department of Neurology, Liaocheng People’s Hospital, Shandong, China [21]Department of Neurology, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China [22]Department of Neurology and Neurosurgery, and Department of Psychiatry, McGill Centre for Studies in Aging, McGill University, Montreal, QC, Canada [23]Chambers-Grundy Center for Transformative Neuroscience, Department of Brain Health, University of Nevada, Las Vegas, NV, USA [24]Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA

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To identify an optimal lifestyle profile to protect against memory loss in older individuals.Population based, prospective cohort study.Participants from areas representative of the north, south, and west of China.Individuals aged 60 years or older who had normal cognition and underwent apolipoprotein E (APOE) genotyping at baseline in 2009.Participants were followed up until death, discontinuation, or 26 December 2019. Six healthy lifestyle factors were assessed: a healthy diet (adherence to the recommended intake of at least 7 of 12 eligible food items), regular physical exercise (≥150 min of moderate intensity or ≥75 min of vigorous intensity, per week), active social contact (≥twice per week), active cognitive activity (≥twice per week), never or previously smoked, and never drinking alcohol. Participants were categorised into the favourable group if they had four to six healthy lifestyle factors, into the average group for two to three factors, and into the unfavourable group for zero to one factor. Memory function was assessed using the World Health Organization/University of California-Los Angeles Auditory Verbal Learning Test, and global cognition was assessed via the Mini-Mental State Examination. Linear mixed models were used to explore the impact of lifestyle factors on memory in the study sample.29 072 participants were included (mean age of 72.23 years; 48.54% (n=14 113) were women; and 20.43% (n=5939) were APOE ε4 carriers). Over the 10 year follow-up period (2009-19), participants in the favourable group had slower memory decline than those in the unfavourable group (by 0.028 points/year, 95% confidence interval 0.023 to 0.032, P<0.001). APOE ε4 carriers with favourable (0.027, 95% confidence interval 0.023 to 0.031) and average (0.014, 0.010 to 0.019) lifestyles exhibited a slower memory decline than those with unfavourable lifestyles. Among people who were not carriers of APOE ε4, similar results were observed among participants in the favourable (0.029 points/year, 95% confidence interval 0.019 to 0.039) and average (0.019, 0.011 to 0.027) groups compared with those in the unfavourable group. APOE ε4 status and lifestyle profiles did not show a significant interaction effect on memory decline (P=0.52).A healthy lifestyle is associated with slower memory decline, even in the presence of the APOE ε4 allele. This study might offer important information to protect older adults against memory decline.ClinicalTrials.gov NCT03653156.© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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出版当年[2021]版：

Q1 MEDICINE, GENERAL & INTERNAL

最新[2023]版：

Q1 MEDICINE, GENERAL & INTERNAL

影响因子： 93.7 最新[2023版] 69.9 最新五年平均 96.216 出版当年[2021版] 65.227 出版当年五年平均 39.89 出版前一年[2020版] 107.7 出版后一年[2022版]

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第一作者机构： [1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China

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Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study