The Characteristics of Cognitive Proficiency in Patients with Acute Neuromyelitis Optica Spectrum Disease and its Correlation with Serum Aquaporin-4 Antibody Titer
机构：[1]Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha 410008, China.[2]Department of Neurology, School of Medicine, South China University of Technology, Guangzhou 510006, China.[3]Department of Neurology, The Sixth Medical Center of Chinese PLA General Hospital of Beijing, Beijing 100048, China.[4]Department of Neurology, Naval Clinical College, Anhui Medical University, Hefei 230032, China.[5]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.神经科系统神经内科首都医科大学宣武医院[6]Senior Department of Neurology, The First Medical Center of PLA General Hospital, Beijing 100853, China.
To explore the characteristics and dynamic evolution of cognitive impairment in patients with neuromyelitis optica spectrum disorder (NMOSD).Twenty-five patients with acute NMOSD and 30 age-matched healthy individuals were consecutively recruited in this study. The Montreal Cognitive Assessment (MoCA), Chinese Version of Rey Auditory Vocabulary Learning Test (CRAVLT), Verbal Fluency Test (VFT), Digital Span Test (DST), Paced Auditory Serial Addition Task 3/2s version (PASAT-3/2), Rey-Osterrieth Complex Figure Test (ROCF) and Stroop Color and Word Test (CWT) were used to evaluate cognitive function. The correlations between cognitive function and serum aquaporin-4 (AQP-4) antibody titer were analyzed.Sixty-four percent of patients with acute NMOSD had cognitive dysfunction. MoCA (p < 0.001), CRAVLT-N7 (p = 0.004), CRAVLT-N8 (p = 0.011), ROCF-C (p = 0.005), ROCF-R (p < 0.001), PASAT-3 (p = 0.013), PASAT-2 (p = 0.001) and CWT-A (p = 0.017) were significantly worse in patients with acute NMOSD than those in control group. During follow-up visits, significant differences of serum AQP-4 antibody titers were still noted in NMOSD patients (p < 0.001), while no significant differences were found by MoCA.A high number of patients with acute NMOSD suffer from cognitive dysfunction. Serum AQP-4 antibody titers can decrease during disease remission, while obvious cognitive decline in these patients still exists.
基金：
This work was supported by Beijing Municipal Science and Technology Commission
(Z181100001718040).
第一作者机构：[1]Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha 410008, China.
共同第一作者：
通讯作者：
通讯机构：[2]Department of Neurology, School of Medicine, South China University of Technology, Guangzhou 510006, China.[3]Department of Neurology, The Sixth Medical Center of Chinese PLA General Hospital of Beijing, Beijing 100048, China.[6]Senior Department of Neurology, The First Medical Center of PLA General Hospital, Beijing 100853, China.
推荐引用方式(GB/T 7714)：
Miao Yan,Zhong Xiaoling,Jia Shuangshuang,et al.The Characteristics of Cognitive Proficiency in Patients with Acute Neuromyelitis Optica Spectrum Disease and its Correlation with Serum Aquaporin-4 Antibody Titer[J].BRAIN SCIENCES.2023,13(1):doi:10.3390/brainsci13010090.
APA：
Miao Yan,Zhong Xiaoling,Jia Shuangshuang,Bian Yang,Han Jinming&Qiu Feng.(2023).The Characteristics of Cognitive Proficiency in Patients with Acute Neuromyelitis Optica Spectrum Disease and its Correlation with Serum Aquaporin-4 Antibody Titer.BRAIN SCIENCES,13,(1)
MLA：
Miao Yan,et al."The Characteristics of Cognitive Proficiency in Patients with Acute Neuromyelitis Optica Spectrum Disease and its Correlation with Serum Aquaporin-4 Antibody Titer".BRAIN SCIENCES 13..1(2023)
