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Resurrection of endogenous retroviruses during aging reinforces senescence

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Liu Xiaoqian[1,5,6,7] * ; Liu Zunpeng[1,5,7] * ; Wu Zeming[2,5,7] * ; Ren Jie[3,5,7] * ; Fan Yanling[3,7] ; Sun Liang[9] ; Cao Gang[8] ; Niu Yuyu[11,12,13] ; Zhang Baohu[1,7] ; Ji Qianzhao[2,7] ; Jiang Xiaoyu[2,7] ; Wang Cui[3,7] ; Wang Qiaoran[3,7] ; Ji Zhejun[1,5,7] ; Li Lanzhu[2,7] ; Esteban Concepcion Rodriguez[18] ; Yan Kaowen[2,5,7] ; Li Wei[4] ; Cai Yusheng[2,5,7] ; Wang Si[4,5,7,15,16] ; Zheng Aihua[7,19] ; Zhang Yong E[7,14] ; Tan Shengjun[14] ; Cai Yingao[7,14] ; Song Moshi[2,5,6,7] ; Lu Falong[7,10] ; Tang Fuchou[17] ; Ji Weizhi[11,12] ; Zhou Qi[1,5,6,7] ; Belmonte Juan Carlos Izpisua[18] ; Zhang Weiqi[3,5,7] ; Qu Jing[1,5,6,7] ; Liu Guang-Hui[2,4,5,6,7] ;
机构： [1]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China [4]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China [5]Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [6]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [7]University of Chinese Academy of Sciences, Beijing 100049, China [8]State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China [9]NHC Beijing Institute of Geriatrics, NHC Key Laboratory of Geriatrics, Institute of Geriatric Medicine of Chinese Academy of Medical Sciences, National Center of Gerontology/Beijing Hospital, Beijing 100730, China [10]State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China [11]State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China [12]Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan 650500, China [13]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, China [14]Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [15]Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China [16]The Fifth People’s Hospital of Chongqing, Chongqing 400062, China [17]Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China [18]Altos Labs, Inc., San Diego, CA 94022, USA [19]State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
出处：
DOI： 10.1016/j.cell.2022.12.017
ISSN：

摘要：
Whether and how certain transposable elements with viral origins, such as endogenous retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the aging process is largely unknown. In human senescent cells, we found that HERVK (HML-2), the most recently integrated human ERVs, are unlocked to transcribe viral genes and produce retrovirus-like particles (RVLPs). These HERVK RVLPs constitute a transmissible message to elicit senescence phenotypes in young cells, which can be blocked by neutralizing antibodies. The activation of ERVs was also observed in organs of aged primates and mice as well as in human tissues and serum from the elderly. Their repression alleviates cellular senescence and tissue degeneration and, to some extent, organismal aging. These findings indicate that the resurrection of ERVs is a hallmark and driving force of cellular senescence and tissue aging.Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

基金：
This work was supported by the National Key R&D Programof China (2020YFA0804000), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16000000), the National Key R&D Program of China (2022YFA1103700, 2018YFC2000100, 2018YFA0107203, 2020YFA0112200, 2019YFA0802202, 2020YFA0803401, 2021YFF1201005, 2022YFA1103800, and 2019YFA0110100), the National Natural Science Foundation of China (81921006, 82125011, 92149301, 92168201, 91949209, 92049304, 92049116, 32121001, 82192863, 82122024, 82071588, 31970597, 81861168034, 31900524, 32100937, 32000510, 32200610, and 82201727), the STI2030-Major Projects (2021ZD0202400), the CAS Project for Young Scientists in Basic Research (YSBR-076 and YSBR-012), the Program of the Beijing Natural Science Foundation (Z190019), K. C. Wong Education Foundation (GJTD-2019-06, GJTD-2019-08), the Pilot Project for Public Welfare Development and Reform of Beijing-affiliated Medical Research Institutes (11000022T000000461062), the Youth Innovation Promotion Association of CAS (E1CAZW0401), the Young Elite Scientists Sponsorship Program by CAST (YESS20200012), the Informatization Plan of Chinese Academy of Sciences (CAS-WX2021SF-0301, CAS-WX2022SDC-XK14, and CAS-WX2021SF- 0101), and the Tencent Foundation (2021-1045).
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
最新[2023]版：
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
JCR分区：
出版当年[2021]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [5]Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [6]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [7]University of Chinese Academy of Sciences, Beijing 100049, China
共同第一作者：
通讯作者：
通讯机构： [1]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China [4]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China [5]Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [6]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [7]University of Chinese Academy of Sciences, Beijing 100049, China
推荐引用方式(GB/T 7714)：
Liu Xiaoqian,Liu Zunpeng,Wu Zeming,et al.Resurrection of endogenous retroviruses during aging reinforces senescence[J].CELL.2023,186(2):287-+.doi:10.1016/j.cell.2022.12.017.
APA：
Liu Xiaoqian,Liu Zunpeng,Wu Zeming,Ren Jie,Fan Yanling...&Liu Guang-Hui.(2023).Resurrection of endogenous retroviruses during aging reinforces senescence.CELL,186,(2)
MLA：
Liu Xiaoqian,et al."Resurrection of endogenous retroviruses during aging reinforces senescence".CELL 186..2(2023):287-+

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