详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Frequency-dependent functional alterations in people living with HIV with early stage of HIV-associated neurocognitive disorder

63| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing, China. [2]Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [3]Department of Radiology, Beijing Second Hospital, Beijing, China. [4]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China. [5]Physical Examination Center, Cangzhou Central Hospital, Cangzhou, Hebei, China. [6]Department of Neurosurgery, Zhuhai People's Hospital, Zhuhai, Guangdong, China.

出处：

DOI：

ISSN：

摘要：

HIV enters the brain soon after seroconversion and causes HIV-associated neurocognitive disorder (HAND). However, the pathogenesis of this insidious impairment at an early stage remains unclear.To explore functional integration and segregation changes at the early stages of HAND, voxel-level indices of regional homogeneity (ReHo), the amplitude of low-frequency fluctuations (ALFF), and voxel-mirrored homotopic connectivity (VMHC) under two different frequency bands (slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.073 Hz) were analyzed.Ninety-eight people living with HIV (PLWH) and 44 seronegative controls underwent resting-state functional magnetic resonance imaging. Furthermore, all PLWHs underwent neuropsychological and daily functioning tests. The main effect of the group and the interaction between the group and frequency band were investigated. Finally, the relationship between the altered indices and the cognitive domains was explored.A significant group-by-frequency interaction was demonstrated in the right thalamus for ReHo; for VMHC, the interaction was observed in the bilateral precuneus and paracentral gyrus. The post hoc Bonferroni test indicated that the alteration of ReHo and VMHC could only be detected in slow-5. PLWH showed significantly reduced ALFF in both the frequency bands in the right occipital gyrus and right calcarine. Moreover, some altered functional integration and segregation indices are related to impaired cognitive function.People living with HIV displayed aberrant functional integration and segregation at the early stages of HAND, which is linked to cognitive function. The frequency band of slow-5 might be more sensitive for detecting insidious damage at an early stage.Copyright © 2023 Wang, Liu, Wang, Li, Liu, Liu, Wang and Li.

基金：

语种：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2022]版：

大类 | 2 区

医学

小类 | 3 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区神经科学

JCR分区：

出版当年[2021]版：

Q2 NEUROSCIENCES

最新[2023]版：

Q2 NEUROSCIENCES

影响因子： 3.2 最新[2023版] 4.3 最新五年平均 5.152 出版当年[2021版] 5.582 出版当年五年平均 4.677 出版前一年[2020版] 4.3 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing, China.

共同第一作者：

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：