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Serum metabolomics identified metabolite biomarkers and distinguished maturity-onset diabetes of the young from type 1 diabetes in the Chinese population

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收录情况： ◇ SCIE

作者：
Liu Jieying[1,2] * ; Fu Junling[1,3] * ; Xie Ziyan[1] * ; Ding Lu[1] ; Wang Dongmei[1] ; Yu Miao[1] ; Zhang Qian[1] ; Xie Ting[1,2] ; Xiao Xinhua[1,*1] ;
机构： [1]Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China [2]Department of Medical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China [3]Department of Endocrinology, Bejing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Bejing, 100053, China
出处：
DOI： 10.1016/j.cca.2022.12.019
ISSN：

摘要：
Maturity-onset diabetes of the young (MODY) patients have unique clinical manifestations and need individualized treatments. We identified novel serum metabolic biomarkers to distinguish MODY and explore the possible mechanism of the clinical manifestation and complications of MODY.Fasting serum samples were collected from MODY3 (n = 17), MODY2 (n = 33), type 1 diabetes (T1DM) (n = 34) and healthy individuals (n = 30), and were analyzed using the ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) metabolomic platform.4 metabolites were found significantly fluctuated between groups, including glycerophosphocholine, LysoPC(18:2(9Z,12Z)), sphinganine and l-Phenylalanine. Glycerophosphocholine was selected as a diagnostic biomarker. The the area under the ROC curve (AUC) for distinguishing MODYs from healthy controls and differentiating MODY3 from T1DM reached 1.0. The combination of metabolites also gained good diagnostic value. The AUC of the combination of LysoPC(18:2(9Z,12Z)), sphinganine and l-Phenylalanine for discriminating MODY3 from T1DM was 0.983. Besides, the combination of clinical indices and metabolites helped to better differentiate the 2 MODY subtypes.We identified the metabolic profiles of MODY2 and MODY3 and found promising biomarkers for distinguishing MODY from T1DM, which provides evidence for the pathogenesis and characteristic clinical manifestations of patients with MODY2 and MODY3.Copyright © 2022 Elsevier B.V. All rights reserved.

基金：
This study was funded by grants from the National Natural Science Foundation of China (No.82170854, 81900723), National High Level Hospital Clinical Research Funding (No. 2022-PUMCH-C-019, 2022- PUMCH-B-015), and Fundamental Research Funds for the Central Uni- versities (3332021 094).
语种：
外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 2 区 医学实验技术
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 医学实验技术
JCR分区：
出版当年[2021]版：
Q1 MEDICAL LABORATORY TECHNOLOGY
最新[2023]版：
Q2 MEDICAL LABORATORY TECHNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China [2]Department of Medical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China [*1]Corresponding author at: No. 1 Shuaifuyuan, Wangfujing Street, Dongcheng District, Beijing 100730, P. R. China
推荐引用方式(GB/T 7714)：
Liu Jieying,Fu Junling,Xie Ziyan,et al.Serum metabolomics identified metabolite biomarkers and distinguished maturity-onset diabetes of the young from type 1 diabetes in the Chinese population[J].CLINICA CHIMICA ACTA.2023,539:250-258.doi:10.1016/j.cca.2022.12.019.
APA：
Liu Jieying,Fu Junling,Xie Ziyan,Ding Lu,Wang Dongmei...&Xiao Xinhua.(2023).Serum metabolomics identified metabolite biomarkers and distinguished maturity-onset diabetes of the young from type 1 diabetes in the Chinese population.CLINICA CHIMICA ACTA,539,
MLA：
Liu Jieying,et al."Serum metabolomics identified metabolite biomarkers and distinguished maturity-onset diabetes of the young from type 1 diabetes in the Chinese population".CLINICA CHIMICA ACTA 539.(2023):250-258

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