机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.神经科系统神经内科首都医科大学宣武医院[2]Department of Rehabilitation, Xuanwu Hospital, Capital Medical University, Beijing, China.神经科系统康复医学科首都医科大学宣武医院[3]Department of Neurology, Beijing Sixth Hospital, Beijing, China.[4]Department of Neurology, Rongcheng People's Hospital, Hebei, China.[5]School of Systems Science, Beijing Normal University, Beijing, China.[6]State Key Laboratory of Cognitive Neuroscience and Learning, Faculty of Psychology, Beijing Normal University, Beijing, China.
Research on posterior cortical atrophy (PCA) has focused on cognitive decline, especially visual processing deficits. However, few studies have examined the effects of PCA on activities of daily living (ADL) and their neurofunctional and neuroanatomic bases.To identify brain regions associated with ADL in PCA patients.A total of 29 PCA patients, 35 typical Alzheimer's disease (tAD) patients, and 26 healthy volunteers were recruited. Each subject completed an ADL questionnaire that included basic and instrumental subscales (BADL and IADL, respectively), and underwent hybrid magnetic resonance imaging and 18F fluorodeoxyglucose positron emission tomography. Voxel-wise regression multivariable analysis was conducted to identify specific brain regions associated with ADL.General cognitive status was similar between PCA and tAD patients; however, the former had lower total ADL scores and BADL and IADL scores. All three scores were associated with hypometabolism in bilateral parietal lobes (especially bilateral superior parietal gyri) at the whole-brain level, PCA-related hypometabolism patterns, and PCA-specific hypometabolism patterns. A cluster that included the right superior parietal gyrus showed an ADL×group interaction effect that was correlated with the TADL score in the PCA group (r = -0.6908, p = 9.3599e-5) but not in the tAD group (r = 0.1006, p = 0.5904). There was no significant association between gray matter density and ADL scores.Hypometabolism in bilateral superior parietal lobes contributes to a decline in ADL in patients with PCA and can potentially be targeted by noninvasive neuromodulatory interventions.
基金：
This work was supported by grants from the Bei jing Municipal Science and Technology Committee (no. 7202060) and National Natural Science Founda449
tion of China (nos. 82271464 and 81971011).
第一作者机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.[2]Department of Rehabilitation, Xuanwu Hospital, Capital Medical University, Beijing, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.[2]Department of Rehabilitation, Xuanwu Hospital, Capital Medical University, Beijing, China.[5]School of Systems Science, Beijing Normal University, Beijing, China.[6]State Key Laboratory of Cognitive Neuroscience and Learning, Faculty of Psychology, Beijing Normal University, Beijing, China.[*1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.[*2]School of Systems Science, Beijing Normal University, Beijing 100875, China State Key Laboratory of Cognitive Neuroscience and Learning, Faculty of Psychology, Beijing Normal University, Beijing 100875, China[*3]Department of Rehabilitation, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
推荐引用方式(GB/T 7714)：
Lv Xuedan,Chu Min,Liu Yang,et al.Neurofunctional Correlates of Activities of Daily Living in Patients with Posterior Cortical Atrophy[J].JOURNAL OF ALZHEIMERS DISEASE.2023,93(1):295-305.doi:10.3233/JAD-221229.
APA：
Lv Xuedan,Chu Min,Liu Yang,Jing Donglai,Liu Li...&Wu Liyong.(2023).Neurofunctional Correlates of Activities of Daily Living in Patients with Posterior Cortical Atrophy.JOURNAL OF ALZHEIMERS DISEASE,93,(1)
MLA：
Lv Xuedan,et al."Neurofunctional Correlates of Activities of Daily Living in Patients with Posterior Cortical Atrophy".JOURNAL OF ALZHEIMERS DISEASE 93..1(2023):295-305
