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Comprehensive prognostic effects of systemic inflammation and Insulin resistance in women with breast cancer with different BMI: a prospective multicenter cohort

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Guo‑Tian Ruan [1,2,3] * ; Hai‑Lun Xie [1,2,3] * ; Chun‑Lei Hu [1,2,3] * ; Chen‑An Liu [1,2,3] ; He‑Yang Zhang [1,2,3] ; Qi Zhang [1,2,3] ; Zi‑Wen Wang [1,2,3] ; Xi Zhang [1,2,3] ; Yi‑Zhong Ge [1,2,3] ; Shi‑Qi Lin [1,2,3] ; Meng Tang [1,2,3] ; Meng‑Meng Song [1,2,3] ; Xiao‑Wei Zhang [1,2,3] ; Xiao‑Yue Liu [1,2,3] ; Kang‑Ping Zhang [1,2,3] ; Ming Yang [1,2,3] ; Kai‑Ying Yu [1,2,3] ; Kun‑Hua Wang [4,5] ; Wen Hu [6] ; Li Deng [1,2,3] ; Ming‑Hua Cong [7] ; Han‑Ping Shi [1,2,3] ;
机构： [1]Department of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China. [2]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. [3]Key Laboratory of Cancer FSMP for State Market Regulation, 10 Tie Yi Road, Beijing 100038, China. [4]Yunnan University, Kunming 650091, China. [5]General Surgery Clinical Medical Center of Yunnan Province, Kunming 650032, China. [6]Clinical Nutrition Department, Sichuan University West China Hospital, Chengdu 610041, Sichuan, China. [7]Comprehensive Oncology Department, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100038, China
出处：
DOI： 10.1038/s41598-023-31450-w
ISSN：

摘要：
To investigate the prognostic value of systemic inflammation and insulin resistance in women with breast cancer with different body mass index (BMI). This multicenter, prospective study included 514 women with breast cancer. Multivariate survival analysis showed that patients with high C-reactive protein (CRP), high CRP to albumin ratio (CAR), high lymphocyte to CRP ratio (LCR), high low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (LHR), and high triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-c) were significantly associated with worse prognosis. The mortality rate of patients with both high CAR and high LHR or both low LCR and high LHR were 3.91-fold or 3.89-fold higher than patients with both low CAR and low LHR or both high LCR and low LHR, respectively. Furthermore, the combination of LCR and LHR significantly predicted survival in patients within the high BMI group. The CRP, CAR, LCR, LHR, and TG/HDL-c were associated with poor survival in women with breast cancer. The combination of CAR and LHR or LCR and LHR could better predict the prognostic outcomes of women with breast cancer, while the combination of LCR and LHR could better predict the prognosis of those patients with overweight or obese patients.© 2023. The Author(s).

基金：
This work was supported by the National Key Research and Development Program [Grant No. 2017YFC1309200, 2022YFC2009600] and the Beijing Municipal Science and Technology Commission [Grant No. SCW2018-06].
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
最新[2023]版：
大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
JCR分区：
出版当年[2021]版：
Q2 MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China. [2]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. [3]Key Laboratory of Cancer FSMP for State Market Regulation, 10 Tie Yi Road, Beijing 100038, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China. [2]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. [3]Key Laboratory of Cancer FSMP for State Market Regulation, 10 Tie Yi Road, Beijing 100038, China.
推荐引用方式(GB/T 7714)：
Guo‑Tian Ruan,Hai‑Lun Xie,Chun‑Lei Hu,et al.Comprehensive prognostic effects of systemic inflammation and Insulin resistance in women with breast cancer with different BMI: a prospective multicenter cohort[J].SCIENTIFIC REPORTS.2023,13(1):doi:10.1038/s41598-023-31450-w.
APA：
Guo‑Tian Ruan,Hai‑Lun Xie,Chun‑Lei Hu,Chen‑An Liu,He‑Yang Zhang...&Han‑Ping Shi.(2023).Comprehensive prognostic effects of systemic inflammation and Insulin resistance in women with breast cancer with different BMI: a prospective multicenter cohort.SCIENTIFIC REPORTS,13,(1)
MLA：
Guo‑Tian Ruan,et al."Comprehensive prognostic effects of systemic inflammation and Insulin resistance in women with breast cancer with different BMI: a prospective multicenter cohort".SCIENTIFIC REPORTS 13..1(2023)

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