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Nutrition impact symptoms: Noteworthy prognostic indicators for lung cancer

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收录情况： ◇ SCIE

作者：
Liu Chen-An[1,2,3,4] * ; Liu Tong[1,2,3,4] * ; Li Hui-Chen[5,6] * ; Song Meng-Meng[1,2,3,4] ; Ge Yi-Zhong[1,2,3,4] ; Ruan Guo-Tian[1,2,3,4] ; Deng Li[1,2,3,4] ; Zhang Qi[4,7] ; Xie Hai-Lun[1,2,3,4] ; Lin Shi-Qi[1,2,3,4] ; Shi Jin-Yu[1,2,3,4] ; Shi Han-Ping[1,2,3,4,*1] ;
机构： [1]Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China [2]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China [3]Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, 100038, China [4]Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, 100038, China [5]Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, 300121, China [6]Tianjin Institute of Coloproctology, Tianjin, 300121, China [7]Department of Colorectal Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, 310022, China
出处：
DOI： 10.1016/j.clnu.2023.02.021
ISSN：

关键词： Lung cancer Nutrition impact symptoms Prognosis Inflammation Malnutrition Cachexia

摘要：
Nutrition impact symptoms (NIS) in head and neck cancer are well-studied and are found to be heavy contributors of poor outcome. However, the prevalence and role of NIS in other cancer are less addressed. In this study, we investigated the incidence and prognostic role of NIS in patients with lung cancer.NIS, evaluated by patient-generated subjective global assessment (PG-SGA) in a multicenter real-world prospective study, included loss of appetite, nausea, vomiting, mouth ulcer, constipation, diarrhea, dry mouth, taste change, altered smell, dysphagia, early satiety, and pain. The endpoints were the patients' overall survival (OS) and quality of life (QoL). The COX analysis was used to investigate the relationship between NIS and OS. Interaction analysis and mediation analysis were performed to determine the modifiers and mediator.3634 patients with lung cancer were enrolled in this study, of which 1533 patients had NIS. During the average follow-up of 22.65 months, 1875 deaths occurred. The OS of patients with lung cancer with NIS was lower than that of patients without NIS. NIS (HR, 1.181, 95% CI, 1.073-1.748), loss of appetite (HR, 1.266, 95% CI, 1.137-1.409), vomiting (HR, 1.282, 95% CI, 1.053-1.561), and dysphagia (HR, 1.401, 95% CI, 1.079-1.819) were independent prognostic factors in patients with lung cancer. There were interactions between chemotherapy and primary tumor on NIS . In the relationship between different types of NIS (NIS, loss of appetite, vomiting, dysphagia) and prognosis, the mediating effects of inflammation accounted for 15.76%, 16.49%, 26.32%, and 18.13%, respectively. Meanwhile, these three NIS were closely associated with the occurrence of severe malnutrition and cancer cachexia.42% patients with lung cancer experienced different types of NIS. NIS were independent indicators of malnutrition, cancer cachexia and shorter OS, and closely related to QoL. NIS management is of clinical significance.Copyright © 2023 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

基金：
This work was supported by the National Key Research and Development Program (2022YFC2009600) to Dr. Hanping Shi and funded by Tianjin Key Medical Discipline (Specialty) Construction Project (No: TJYXZDXK-044A).
语种：
外文
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WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 营养学
最新[2023]版：
大类 | 2 区 医学
小类 | 1 区 营养学
JCR分区：
出版当年[2021]版：
Q1 NUTRITION & DIETETICS
最新[2023]版：
Q1 NUTRITION & DIETETICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China [2]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China [3]Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, 100038, China [4]Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, 100038, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China [2]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China [3]Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, 100038, China [4]Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, 100038, China [*1]Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
推荐引用方式(GB/T 7714)：
Liu Chen-An,Liu Tong,Li Hui-Chen,et al.Nutrition impact symptoms: Noteworthy prognostic indicators for lung cancer[J].CLINICAL NUTRITION.2023,42(4):550-558.doi:10.1016/j.clnu.2023.02.021.
APA：
Liu Chen-An,Liu Tong,Li Hui-Chen,Song Meng-Meng,Ge Yi-Zhong...&Shi Han-Ping.(2023).Nutrition impact symptoms: Noteworthy prognostic indicators for lung cancer.CLINICAL NUTRITION,42,(4)
MLA：
Liu Chen-An,et al."Nutrition impact symptoms: Noteworthy prognostic indicators for lung cancer".CLINICAL NUTRITION 42..4(2023):550-558

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