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SESN1 is a FOXO3 effector that counteracts human skeletal muscle ageing

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机构： [1]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. [2]University of Chinese Academy of Sciences, Beijing, China. [3]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, China. [4]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing, China. [5]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China. [6]China National Center for Bioinformation, Beijing, China. [7]The NHC Key Laboratory of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, China. [8]The NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming, Yunnan, China. [9]Aging Biomarker Consortium, Beijing, China. [10]Department of Orthopaedics, Peking University First Hospital, Beijing, China. [11]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. [12]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. [13]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. [14]Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China. [15]Sino-Danish Center for Education and Research, Beijing, China. [16]Altos Labs, San Diego, California, USA. [17]Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University, Third Hospital, Beijing, China. [18]Clinical Stem Cell Research Center, Peking University, Third Hospital, Beijing, China. [19]The Fifth People's Hospital of Chongqing, Chongqing, China.

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Sarcopenia, a skeletal muscle disorder in which loss of muscle mass and function progresses with age, is associated with increased overall frailty, risk of falling and mortality in the elders. Here, we reveal that SESN1 safeguards skeletal muscle from ageing downstream of the longevity gene FOXO3, which we recently reported is a geroprotector in primate skeletal muscle. Knockdown of SESN1 mimicked the human myotube ageing phenotypes observed in the FOXO3-deficient human myotubes, whereas genetic activation of SESN1 alleviated human myotube senescence. Of note, SESN1 was identified as a protective secretory factor against muscle atrophy. Administration of recombinant SESN1 protein attenuated senescence of human myotubes in vitro and facilitated muscle regeneration in vivo. Altogether, we unveil a key role of SESN1 downstream of FOXO3 in protecting skeletal muscle from ageing, providing diagnostic biomarkers and intervention strategies for counteracting skeletal muscle ageing and related diseases.© 2023 The Authors. Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd.

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出版当年[2022]版：

大类 | 1 区

生物学

小类 | 2 区细胞生物学

最新[2023]版：

大类 | 1 区

生物学

小类 | 2 区细胞生物学

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出版当年[2021]版：

Q1 CELL BIOLOGY

最新[2023]版：

Q2 CELL BIOLOGY

影响因子： 5.9 最新[2023版] 7.3 最新五年平均 8.755 出版当年[2021版] 7.834 出版当年五年平均 6.831 出版前一年[2020版] 8.5 出版后一年[2022版]

第一作者：

第一作者机构： [1]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. [2]University of Chinese Academy of Sciences, Beijing, China. [3]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, China. [4]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing, China.

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通讯作者：

通讯机构： [1]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. [2]University of Chinese Academy of Sciences, Beijing, China. [3]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, China. [4]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing, China. [9]Aging Biomarker Consortium, Beijing, China. [11]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. [12]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. [13]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. [17]Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University, Third Hospital, Beijing, China. [18]Clinical Stem Cell Research Center, Peking University, Third Hospital, Beijing, China. [19]The Fifth People's Hospital of Chongqing, Chongqing, China. [*1]Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University Third Hospital, Beijing 100191, China. [*2]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Beijing 100101, China. [*3]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. [*4]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China.

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