机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China神经科系统神经内科首都医科大学宣武医院[2]Beijing Key Laboratory of Neuromodulation, Beijing, China[3]State Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing,China[4]Hefei Comprehensive National Science Center, Institute of Artificial Intelligence, Hefei, China[5]Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China[6]Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China[7]Institute of Sleep and Consciousness Disorders, Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China[8]Hebei Hospital of Xuanwu Hospital, Capital Medical University, Shijiazhuang, China首都医科大学宣武医院[9]Neuromedical Technology Innovation Center of Hebei Province, Shijiazhuang, China
AimsTranscranial focus ultrasound stimulation (tFUS) is a promising non-invasive neuromodulation technology. This study aimed to evaluate the modulatory effects of tFUS on human motor cortex (M1) excitability and explore the mechanism of neurotransmitter-related intracortical circuitry and plasticity. MethodsSingle pulse transcranial magnetic stimulation (TMS)-eliciting motor-evoked potentials (MEPs) were used to assessed M1 excitability in 10 subjects. Paired-pulse TMS was used to measure the effects of tFUS on GABA- and glutamate-related intracortical excitability and H-1-MRS was used to assess the effects of repetitive tFUS on GABA and Glx (glutamine + glutamate) neurometabolic concentrations in the targeting region in nine subjects. ResultsThe etFUS significantly increased M1 excitability, decreased short interval intracortical inhibition (SICI) and long interval intracortical inhibition (LICI). The itFUS significantly suppressed M1 excitability, increased SICI, LICI, and decreased intracortical facilitation (ICF). Seven times of etFUS decreased the GABA concentration (6.32%), increased the Glx concentration (12.40%), and decreased the GABA/Glx ratio measured by MRS, while itFUS increased the GABA concentration (18.59%), decreased Glx concentration (0.35%), and significantly increased GABA/Glx ratio. ConclusionThe findings support that tFUS with different parameters can exert excitatory and inhibitory neuromodulatory effects on the human motor cortex. We provide novel insights that tFUS change cortical excitability and plasticity by regulating excitatory-inhibition balance related to the GABAergic and glutamatergic receptor function and neurotransmitter metabolic level.
基金：
National Natural Science Foundation of China [82071483, 2021ZD0201801]; Natural Science Foundation of Beijing [7212048]; National Key R&D Program of China [2021YFC2501400, 2021YFC2501403, 2017YFE0118800]; Ministry of Science and Technology of China [2020AAA0105601, 2019YFA0707103]; University Synergy Innovation Program of Anhui Province [GXXT-2021-002]; Jiliang Fang (Department of Radiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China)
第一作者机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China[2]Beijing Key Laboratory of Neuromodulation, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China[2]Beijing Key Laboratory of Neuromodulation, Beijing, China[7]Institute of Sleep and Consciousness Disorders, Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China[8]Hebei Hospital of Xuanwu Hospital, Capital Medical University, Shijiazhuang, China[9]Neuromedical Technology Innovation Center of Hebei Province, Shijiazhuang, China[*1]Department of Neurology, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, 100053 Beijing, China.
推荐引用方式(GB/T 7714)：
Zhang Tingting,Guo Bingqi,Zuo Zhentao,et al.Excitatory-inhibitory modulation of transcranial focus ultrasound stimulation on human motor cortex[J].CNS NEUROSCIENCE & THERAPEUTICS.2023,29(12):3829-3841.doi:10.1111/cns.14303.
APA：
Zhang, Tingting,Guo, Bingqi,Zuo, Zhentao,Long, Xiaojing,Hu, Shimin...&Liu, Chunyan.(2023).Excitatory-inhibitory modulation of transcranial focus ultrasound stimulation on human motor cortex.CNS NEUROSCIENCE & THERAPEUTICS,29,(12)
MLA：
Zhang, Tingting,et al."Excitatory-inhibitory modulation of transcranial focus ultrasound stimulation on human motor cortex".CNS NEUROSCIENCE & THERAPEUTICS 29..12(2023):3829-3841
医学