机构：[1]Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric and Gynecologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[2]Neurospine Center, Xuanwu Hospital, National Center for Neurological Disorders, China International Neuroscience Institute (CHINA-INI), Capital Medical University, Beijing, China首都医科大学宣武医院
Objective Ovarian clear cell carcinoma (OCCC) is a distinct entity from epithelial ovarian cancer. The prognosis of advanced and recurrent disease is very poor due to resistance to chemotherapeutic agents. Our aim was to explore the molecular alterations among OCCC patients with different chemotherapeutic responses and to obtain insights into potential biomarkers.Methods Twenty-four OCCC patients were included in this study. The patients were divided into two groups based on the relapse time after the first-line platinum-based chemotherapy: the platinum-sensitive group (PS) and the platinum-resistant group (PR). Gene expression profiling was performed using NanoString nCounter PanCancer Pathways Panel.Results Gene expression analysis comparing PR vs. PS identified 32 differentially expressed genes: 17 upregulated genes and 15 downregulated genes. Most of these genes are involved in the PI3K, MAPK and Cell Cycle-Apoptosis pathways. In particular, eight genes are involved in two or all three pathways.Conclusion The dysregulated genes in the PI3K, MAPK, and Cell Cycle-Apoptosis pathways identified and postulated mechanisms could help to probe biomarkers of OCCC platinum sensitivity, providing a research basis for further exploration of targeted therapy. [GRAPHICS]
基金：
National Key Research and Development Program of China [2022YFC2704202]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|3 区医学
小类|3 区妇产科学3 区公共卫生、环境卫生与职业卫生
最新[2025]版：
大类|3 区医学
小类|3 区妇产科学3 区公共卫生、环境卫生与职业卫生
JCR分区：
出版当年[2021]版：
Q3OBSTETRICS & GYNECOLOGYQ3PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
最新[2023]版：
Q2OBSTETRICS & GYNECOLOGYQ2PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
第一作者机构：[1]Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric and Gynecologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Yin Min,Lu Chunli,Zhou Huimei,et al.Differential molecular pathway expression according to chemotherapeutic response in ovarian clear cell carcinoma[J].BMC WOMENS HEALTH.2023,23(1):doi:10.1186/s12905-023-02420-1.
APA：
Yin, Min,Lu, Chunli,Zhou, Huimei,Liu, Qian&Yang, Jiaxin.(2023).Differential molecular pathway expression according to chemotherapeutic response in ovarian clear cell carcinoma.BMC WOMENS HEALTH,23,(1)
MLA：
Yin, Min,et al."Differential molecular pathway expression according to chemotherapeutic response in ovarian clear cell carcinoma".BMC WOMENS HEALTH 23..1(2023)
