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Generation of induced pluripotent stem cell line (XWHNi002-A) from a female with APP gene mutation

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Sun Wenxian[1] * ; Wang Pin[1] ; Gong Jin[2] ; Chen Yufei[1] ; Yang Yuting[3] ; Luan Heya[1] ; Li Shaoqi[2] ; Li Ruina[3] ; Wei Cuibai[1] ;
机构： [1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for [2]College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China [3]School of Biological Science and Medical Engineering, Beihang University, Beijing, China
出处：
DOI： 10.1016/j.scr.2023.103149
ISSN：

摘要：
The β-amyloid precursor protein (APP) is a crucial pathogenic gene linked to Alzheimer's disease (AD). A human induced pluripotent stem cell (iPSC) line was generated from peripheral blood mononuclear cells (PBMCs) isolated from a female with APP gene mutation utilizing non-integrative Sendai virus. The iPSC line exhibits high expression of pluripotency markers, retains the APP mutation, displays a normal karyotype, and has the ability to differentiate into normal teratoma tissue. This iPSC line represents a valuable cell model for investigating the pathological mechanisms and therapeutic strategies of AD.Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

基金：
This study was supported by STI2030-Major Projects (No.2021ZD0201802) to Dr. Cuibai Wei.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 4 区 医学
小类 | 4 区 生物工程与应用微生物 4 区 细胞与组织工程 4 区 细胞生物学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 生物工程与应用微生物 4 区 细胞与组织工程 4 区 细胞生物学
JCR分区：
出版当年[2021]版：
Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q4 CELL & TISSUE ENGINEERING Q4 CELL BIOLOGY
最新[2023]版：
Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q4 CELL & TISSUE ENGINEERING Q4 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for
通讯作者：
推荐引用方式(GB/T 7714)：
Sun Wenxian,Wang Pin,Gong Jin,et al.Generation of induced pluripotent stem cell line (XWHNi002-A) from a female with APP gene mutation[J].STEM CELL RESEARCH.2023,71:doi:10.1016/j.scr.2023.103149.
APA：
Sun Wenxian,Wang Pin,Gong Jin,Chen Yufei,Yang Yuting...&Wei Cuibai.(2023).Generation of induced pluripotent stem cell line (XWHNi002-A) from a female with APP gene mutation.STEM CELL RESEARCH,71,
MLA：
Sun Wenxian,et al."Generation of induced pluripotent stem cell line (XWHNi002-A) from a female with APP gene mutation".STEM CELL RESEARCH 71.(2023)

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