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Pipeline Embolization Device for intracranial aneurysms presenting with mass effect: a large Chinese cohort

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机构： [1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [2]Department of Neurosurgery, Peking University International Hospital, Beijing, China [3]Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China [4]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [5]Department of Interventional Neuroradiology, Zhengzhou University People's Hospital, Zhengzhou, Henan, China [6]Department of Neurosurgery, Shanghai Donglei Brain Hospital, Shanghai, China [7]Department of Interventional Neuroradiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China [8]Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China [9]Department of Neurosurgery, Qilu Hospital of Shandong University Qingdao, Jinan, Shandong, China [10]Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China [11]Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China [12]Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China [13]Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China [14]Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China [15]Department of Neurosurgery, Changhai Hospital, Naval Medical University, Shanghai, China

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Unruptured intracranial aneurysm treatment aims to reduce the risk of aneurysm rupture and bleeding, relieves symptoms and improve the quality of life for patients. This study aimed to assess the safety and efficacy of Pipeline Embolization Device (PED, Covidien/Medtronic, Irvine, CA) treatment for intracranial aneurysms presenting with mass effect in real-world settings.We selected patients from the PED in China Post-Market Multi-Center Registry Study with mass effect presentation. The study endpoints included postoperative mass effect deterioration and mass effect relief at follow-up (3-36 months). We conducted multivariate analysis to identify factors associated with mass effect relief. Subgroup analyses by aneurysm location, size and form were also performed.This study included 218 patients with a mean age of 54.3±11.8 years and a female predominance of 74.0% (162/218). The postoperative mass effect deterioration rate was 9.6% (21/218). During a median follow-up period of 8.4 months, the mass effect relief rate was 71.6% (156/218). Notably, immediate aneurysm occlusion following treatment was significantly associated with mass effect relief (OR 0.392, 95% CI, 0.170 to 0.907, p=0.029). Subgroup analysis demonstrated that adjunctive coiling contributed to mass effect relief in cavernous aneurysms, while dense embolism impeded symptom relief in aneurysms<10 mm and saccular aneurysms.Our data confirmed the efficacy of PED in relieving mass effect. The findings of this study provide support for endovascular treatment to alleviate mass effect in unruptured intracranial aneurysms.NCT03831672.© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.

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出版当年[2023]版：

大类 | 1 区医学

小类 | 2 区临床神经病学

最新[2023]版：

大类 | 1 区医学

小类 | 2 区临床神经病学

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出版当年[2022]版：

Q1 CLINICAL NEUROLOGY

最新[2023]版：

Q1 CLINICAL NEUROLOGY

影响因子： 4.4 最新[2023版] 6 最新五年平均 5.9 出版当年[2022版] 7.3 出版当年五年平均 9.893 出版前一年[2021版] 4.4 出版后一年[2023版]

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第一作者机构： [1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [2]Department of Neurosurgery, Peking University International Hospital, Beijing, China

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