机构：[1]Xuanwu Hospital, Capital Medical University, Department of Otorhinolaryngology Head and Neck Surgery, Beijing, China外科系统耳鼻咽喉-头颈外科首都医科大学宣武医院[2]The Fifth People’s Hospital of Datong, Department of Neurosurgery, Datong, Shanxi, China[3]Xuanwu Hospital Capital Medical University, Department of Neurosurgery, Beijing China神经科系统神经外科首都医科大学宣武医院
About 6-17% of pituitary neuroendocrine tumors (PitNETs) are invasive. Cavernous sinus invasion complicates neurosurgery, making total tumor resection impossible and leading to high recurrence postoperatively. This study detected Endocan, FGF2, and PDGF to examine the associations of these angiogenic factors with the invasiveness of PitNETs and to identify novel therapeutic targets in PitNETs.Endocan mRNA amounts (qRT-PCR) in 29 human PitNET specimens obtained after surgery were assessed alongside clinical parameters (PitNET lineage, sex, age, and imaging data). In addition, qRT-PCR was used to determine the gene expression of other angiogenic markers (FGF-2 and PDGF).Endocan was positively associated with PitNET invasiveness. Endocan expressing specimens had elevated FGF2 amounts, and FGF2 and PDGF were negatively correlated.A complex but precise balance was found among Endocan, FGF2, and PDGF in pituitary tumorigenesis. High Endocan and FGF2 and low PDGF expression levels in invasive PitNETs show Endocan and FGF2 could be novel treatment targets in invasive PitNET.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|4 区医学
小类|4 区临床神经病学4 区外科
最新[2023]版：
大类|4 区医学
小类|4 区临床神经病学4 区外科
第一作者：
第一作者机构：[1]Xuanwu Hospital, Capital Medical University, Department of Otorhinolaryngology Head and Neck Surgery, Beijing, China
通讯作者：
推荐引用方式(GB/T 7714)：
Tao Pengyu,Liu Xiaofeng,Zhang Qiuhang,et al.Associations of Endocan, FGF2, and PDGF Expression with Pituitary Neuroendocrine Tumor (PitNET) Invasiveness[J].Turkish neurosurgery.2022,doi:10.5137/1019-5149.JTN.40216-22.4.
APA：
Tao Pengyu,Liu Xiaofeng,Zhang Qiuhang,Chen Ge&Ling Feng.(2022).Associations of Endocan, FGF2, and PDGF Expression with Pituitary Neuroendocrine Tumor (PitNET) Invasiveness.Turkish neurosurgery,,
MLA：
Tao Pengyu,et al."Associations of Endocan, FGF2, and PDGF Expression with Pituitary Neuroendocrine Tumor (PitNET) Invasiveness".Turkish neurosurgery .(2022)
