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Evidence of a large current of transcranial alternating current stimulation directly to deep brain regions

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Shan Yongzhi[1,2,3] * ; Wang Hongxing[4,5] * ; Yang Yanfeng[1,2,3] ; Wang Jiahao[6,7] ; Zhao Wenfeng[4] ; Huang Yuda[1,2,3] ; Wang Huang[4] ; Han Bing[4] ; Pan Na[4] ; Jin Xiukun[4] ; Fan Xiaotong[1,2,3] ; Liu Yunyun[1,2,3] ; Wang Jun[1,2,3] ; Wang Changming[1,2,3] ; Zhang Huaqiang[1,2,3] ; Chen Sichang[1,2,3] ; Liu Ting[1,2,3] ; Yan Tianyi[8] ; Si Tianmei[9] ; Yin Lu[10] ; Li Xinmin[11] ; Cosci Fiammetta[12] ; Zhang Xiangyang[13] ; Zhang Guanghao[6,7] ; Gao Keming[14,15] ; Zhao Guoguang[1,2,3,16] ;
机构： [1]Department of Neurosurgery, Xuanwu Hospital, National Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Capital Medical University, Beijing 100053, China. [2]China International Neuroscience Institute (CHINA-INI), Beijing 100053, China. [3]Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China. [4]Division of Neuropsychiatry and Psychosomatics, Department of Neurology, Xuanwu Hospital, National Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Capital Medical University, Beijing 100053, China. [5]Beijing Institute of Brain Disorders, Beijing 100069, China. [6]Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, China. [7]School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, China. [8]School of Life Science, Beijing Institute of Technology, Beijing 100081, China. [9]Peking University Sixth Hospital, Peking University Institute of Mental Health, National Clinical Research Center for Mental Disorders, Beijing 100191, China. [10]Medical Research & Biometrics Centre, Fuwai Hospital, National Centre for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 102300, China. [11]Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Albert T6G 2B7, Canada. [12]Department of Health Sciences, University of Florence, Florence 50135, Italy. [13]CAS Key Laboratory of Mental Health, Chinese Academy of Sciences, Beijing 100101, China. [14]Department of Psychiatry, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA [15]Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. [16]Center of Epilepsy, Beijing Institute of Brain Disorders, Beijing 100069, China.
出处：
DOI： 10.1038/s41380-023-02150-8
ISSN：

摘要：
Deep brain regions such as hippocampus, insula, and amygdala are involved in neuropsychiatric disorders, including chronic insomnia and depression. Our recent reports showed that transcranial alternating current stimulation (tACS) with a current of 15 mA and a frequency of 77.5 Hz, delivered through a montage of the forehead and both mastoids was safe and effective in intervening chronic insomnia and depression over 8 weeks. However, there is no physical evidence to support whether a large alternating current of 15 mA in tACS can send electrical currents to deep brain tissue in awake humans. Here, we directly recorded local field potentials (LFPs) in the hippocampus, insula and amygdala at different current strengths (1 to 15 mA) in 11 adult patients with drug-resistant epilepsy implanted with stereoelectroencephalography (SEEG) electrodes who received tACS at 77.5 Hz from 1 mA to 15 mA at 77.5 Hz for five minutes at each current for a total of 40 min. For the current of 15 mA at 77.5 Hz, additional 55 min were applied to add up a total of 60 min. Linear regression analysis revealed that the average LFPs for the remaining contacts on both sides of the hippocampus, insula, and amygdala of each patient were statistically associated with the given currents in each patient (p < 0.05-0.01), except for the left insula of one subject (p = 0.053). Alternating currents greater than 7 mA were required to produce significant differences in LFPs in the three brain regions compared to LFPs at 0 mA (p < 0.05). The differences remained significant after adjusting for multiple comparisons (p < 0.05). Our study provides direct evidence that the specific tACS procedures are capable of delivering electrical currents to deep brain tissues, opening a realistic avenue for modulating or treating neuropsychiatric disorders associated with hippocampus, insula, and amygdala.© 2023. The Author(s).

基金：
This study protocol was reviewed and approved by Xuanwu Hospital Capital Medical University (No. LYS-[2020]- 051), and is a part of a clinical trial registered at ClinicalTrials.gov (NCT04560959).
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 生化与分子生物学 1 区 神经科学 1 区 精神病学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 生化与分子生物学 1 区 神经科学 1 区 精神病学
JCR分区：
出版当年[2021]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 NEUROSCIENCES Q1 PSYCHIATRY
最新[2023]版：
Q1 NEUROSCIENCES Q1 PSYCHIATRY Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Neurosurgery, Xuanwu Hospital, National Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Capital Medical University, Beijing 100053, China. [2]China International Neuroscience Institute (CHINA-INI), Beijing 100053, China. [3]Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Neurosurgery, Xuanwu Hospital, National Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Capital Medical University, Beijing 100053, China. [2]China International Neuroscience Institute (CHINA-INI), Beijing 100053, China. [3]Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China. [4]Division of Neuropsychiatry and Psychosomatics, Department of Neurology, Xuanwu Hospital, National Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Capital Medical University, Beijing 100053, China. [5]Beijing Institute of Brain Disorders, Beijing 100069, China. [6]Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, China. [7]School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, China. [14]Department of Psychiatry, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA [15]Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. [16]Center of Epilepsy, Beijing Institute of Brain Disorders, Beijing 100069, China.
推荐引用方式(GB/T 7714)：
Shan Yongzhi,Wang Hongxing,Yang Yanfeng,et al.Evidence of a large current of transcranial alternating current stimulation directly to deep brain regions[J].MOLECULAR PSYCHIATRY.2023,28(12):5402-5410.doi:10.1038/s41380-023-02150-8.
APA：
Shan Yongzhi,Wang Hongxing,Yang Yanfeng,Wang Jiahao,Zhao Wenfeng...&Zhao Guoguang.(2023).Evidence of a large current of transcranial alternating current stimulation directly to deep brain regions.MOLECULAR PSYCHIATRY,28,(12)
MLA：
Shan Yongzhi,et al."Evidence of a large current of transcranial alternating current stimulation directly to deep brain regions".MOLECULAR PSYCHIATRY 28..12(2023):5402-5410

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