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Determining a multimodal aging clock in a cohort of Chinese women

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收录情况： ◇ ESCI

作者：
Li Jiaming[1,6] * ; Xiong Muzhao[1,6] * ; Fu Xiang-Hong[2,9] * ; Fan Yanling[1,6] * ; Dong Chen[14,16] * ; Sun Xiaoyan[1,6] ; Zheng Fang[9] ; Wang Si-Wei[9] ; Liu Lixiao[1,6] ; Xu Ming[14] ; Wang Cui[1,6] ; Ping Jiale[1,6] ; Che Shanshan[1,6] ; Wang Qiaoran[1,6] ; Yang Kuan[1,6] ; Zuo Yuesheng[1,6] ; Lu Xiaoyong1,61][1] ; Zheng Zikai[1,6] ; Lan Tian[9] ; Wang Si[3,12,13] ; Ma Shuai[3,5,10,11] ; Sun Shuhui[5,10,11] ; Zhang Bin[1] ; Chen Chen-Shui[8,9] ; Cheng Ke-Yun[9] ; Ye Jinlin[9] ; Qu Jing[3,6,7,10,11] ; Xue Yongbiao[1,6] ; Yang Yun-Gui[1,6] ; Zhang Feng[2,4,9] ; Zhang Weiqi[1,3,6,10] ; Liu Guang-Hui[3,5,6,10,11,12,13] ;
机构： [1]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China [2]Center for Reproductive Medicine, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou 324000, China [3]Aging Biomarker Consortium, Beijing 100101, China [4]The Joint Innovation Center for Engineering in Medicine, Quzhou People’s Hospital, Quzhou 324000, China [5]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [6]University of the Chinese Academy of Sciences, Beijing 100049, China [7]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [8]Department of Respiratory and Critical Care Medicine, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou 324000, China [9]Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou 324000, China [10]Institute for Stem Cell and Regeneration, CAS, Beijing 100101, China [11]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [12]Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [13]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [14]State Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, Beijing 100876, China
出处：
DOI： 10.1016/j.medj.2023.06.010
ISSN：

摘要：
Translating aging rejuvenation strategies into clinical practice has the potential to address the unmet needs of the global aging population. However, to successfully do so requires precise quantification of aging and its reversal in a way that encompasses the complexity and variation of aging.Here, in a cohort of 113 healthy women, tiled in age from young to old, we identified a repertoire of known and previously unknown markers associated with age based on multimodal measurements, including transcripts, proteins, metabolites, microbes, and clinical laboratory values, based on which an integrative aging clock and a suite of customized aging clocks were developed.A unified analysis of aging-associated traits defined four aging modalities with distinct biological functions (chronic inflammation, lipid metabolism, hormone regulation, and tissue fitness), and depicted waves of changes in distinct biological pathways peak around the third and fifth decades of life. We also demonstrated that the developed aging clocks could measure biological age and assess partial aging deceleration by hormone replacement therapy, a prevalent treatment designed to correct hormonal imbalances.We established aging metrics that capture systemic physiological dysregulation, a valuable framework for monitoring the aging process and informing clinical development of aging rejuvenation strategies.This work was supported by the National Natural Science Foundation of China (32121001), the National Key Research and Development Program of China (2022YFA1103700 and 2020YFA0804000), the National Natural Science Foundation of China (81502304), and the Quzhou Technology Projects (2022K46).Copyright © 2023 Elsevier Inc. All rights reserved.

基金：
This work was supported by the National Natural Science Foundation of China (32121001), the National Key Research and Development Program of China (2022YFA1103700 and 2020YFA0804000), the National Natural Science Foundation of China (81502304), and the Quzhou Technology Projects (2022K46).
语种：
外文
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出版当年[2021]版：
无
最新[2023]版：
Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China [6]University of the Chinese Academy of Sciences, Beijing 100049, China
共同第一作者：
通讯作者：
通讯机构： [1]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China [2]Center for Reproductive Medicine, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou 324000, China [3]Aging Biomarker Consortium, Beijing 100101, China [4]The Joint Innovation Center for Engineering in Medicine, Quzhou People’s Hospital, Quzhou 324000, China [5]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [6]University of the Chinese Academy of Sciences, Beijing 100049, China [9]Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou 324000, China [10]Institute for Stem Cell and Regeneration, CAS, Beijing 100101, China [11]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [12]Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [13]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Li Jiaming,Xiong Muzhao,Fu Xiang-Hong,et al.Determining a multimodal aging clock in a cohort of Chinese women[J].MED.2023,4(11):825-+.doi:10.1016/j.medj.2023.06.010.
APA：
Li Jiaming,Xiong Muzhao,Fu Xiang-Hong,Fan Yanling,Dong Chen...&Liu Guang-Hui.(2023).Determining a multimodal aging clock in a cohort of Chinese women.MED,4,(11)
MLA：
Li Jiaming,et al."Determining a multimodal aging clock in a cohort of Chinese women".MED 4..11(2023):825-+

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