机构：[1]Department of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.[2]Department of Neurology, West China Hospital of Sichuan University, Sichuan, China.四川大学华西医院[3]Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.[4]Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.重庆医科大学附属第一医院[5]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.神经科系统神经内科首都医科大学宣武医院[6]Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.苏州大学附属第二医院[7]Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Jiangsu, China.[8]Department of Neurology, Xiangya Hospital Central South University, Changsha, China.[9]Department of Neurology, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China.广东省人民医院[10]Internal Medicine-Neurology, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China.[11]Department of Neurology, Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, Hubei, China.华中科技大学同济医学院附属协和医院[12]Department of Neurology, Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.[13]Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.[14]Department of Neurology, The First Affiliated hospital of Anhui Medical University, Anhui, China.[15]Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.[16]Department & Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.[17]Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.中山大学附属第二医院[18]Department of Neurology & Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Nocturnal symptoms have a significant effect on the quality of life in Parkinson's disease (PD) patients.This study aimed to investigate the prevalence and associated factors of nocturnal symptoms in Chinese PD patients.This multicenter cross-sectional study included 1,500 patients with primary PD from 18 centers in China was carried out between February 2019 and February 2020. Questionnaires including Parkinson's disease sleep scale 2 (PDSS-2), Parkinson's disease questionnaire 8 (PDQ-8), Beck depression inventory (BDI), and generalized anxiety disorder scale 7 (GAD-7) were used to assess nocturnal symptoms, quality of life, depression, and anxiety.Among 1,500 Chinese PD patients, 576 (38.4%) reported nocturnal symptoms. Of them, 59.2% were older than 65 years. The PDQ-8 total score was higher in patients with nocturnal symptoms (p < 0.01). Moderate and severe depression was reported more often in patients with nocturnal symptoms (p < 0.01), and the occurrence and severity of anxiety were higher as well (p < 0.01). Longer disease duration and higher Hoehn-Yahr (HY) stage were independently associated with nocturnal symptoms (p < 0.01). Education level, depression, disease course, HY stage, and nocturnal symptoms were related to the quality of life in Chinese PD patients (p < 0.01).Our study found that 38.4% of Chinese PD patients have nocturnal symptoms, even in early and mid-stage PD. Nocturnal symptoms were associated with worse quality of life and higher incidences of depression and anxiety. Nocturnal symptoms should be included in the assessment and care plan, especially in patients with longer disease courses and higher HY stages.
第一作者机构：[1]Department of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Su Wen,Ma Xinxin,Shang Huifang,et al.Evaluation of Nocturnal Symptoms in Chinese Parkinson's Disease Patients Based on the PDSS-2 Scale: A Multicenter Cross-Sectional Study[J].JOURNAL OF PARKINSONS DISEASE.2023,13(6):1063-1073.doi:10.3233/JPD-230060.
APA：
Su Wen,Ma Xinxin,Shang Huifang,Ye Qinyong,Cheng Oumei...&Chen Haibo.(2023).Evaluation of Nocturnal Symptoms in Chinese Parkinson's Disease Patients Based on the PDSS-2 Scale: A Multicenter Cross-Sectional Study.JOURNAL OF PARKINSONS DISEASE,13,(6)
MLA：
Su Wen,et al."Evaluation of Nocturnal Symptoms in Chinese Parkinson's Disease Patients Based on the PDSS-2 Scale: A Multicenter Cross-Sectional Study".JOURNAL OF PARKINSONS DISEASE 13..6(2023):1063-1073
