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High-Frequency rTMS Could Improve Impaired Memory in Mild Cognitive Impairment Patients in China: A Randomized Controlled Study

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机构： [1]Department of Radiology and Institute of Rehabilitation and Imaging of Brain Function, Nanchong Central Hospital, North Sichuan Medical College, Nanchong. [2]Department of Radiology, Xuanwu Hospital, Capital Medical University. [3]National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu. [4]Department of Radiology, Hospital of Traditional Chinese Medicine of Leshan, Leshan, China. [5]Department of Radiology, Peking University Third Hospital, Beijing.

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The purpose of this study was to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on improving memory deficits in mild cognitive impairment (MCI), as well as to provide visualized evidence for neuronal specificity by using resting-state functional magnetic resonance imaging.Forty MCI patients were enrolled to receive 10-session and sham-controlled 10Hz-rTMS over the left dorsolateral prefrontal cortex. The resting-state functional magnetic resonance imaging combined with memory scales assessment were performed before and after the intervention. To elucidate the therapeutic mechanism of rTMS, amplitude of low-frequency fluctuations (ALFF) and functional connectivity were calculated. The Pearson correlation was used to measure the relationship between ALFF and memory performance.Compared with the sham group, ALFF significantly increased in the right insula, right inferior frontal gyrus-opercular part, and decreased in the left middle occipital gyrus, left angular gyrus, and left lingual gyrus after rTMS. The change in Auditory Verbal Learning Test scores were negatively correlated with ALFF decreases in the left lingual gyrus. Functional connectivity significantly increased between the posterior cingulate cortex and right supramarginal gyrus, and decreased between the right frontoinsular cortex and right supramarginal gyrus after intervention.High-frequency rTMS over the left dorsolateral prefrontal cortex could facilitate improvement on impaired memory in patients with MCI via modulating the neuronal activity and brain network.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

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出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区病理学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区病理学

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出版当年[2021]版：

Q3 PATHOLOGY Q4 CLINICAL NEUROLOGY

最新[2024]版：

Q3 PATHOLOGY Q4 CLINICAL NEUROLOGY

影响因子： 1.4 最新[2024版] 2 最新五年平均 2.357 出版当年[2021版] 3.621 出版当年五年平均 2.703 出版前一年[2020版] 2.1 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Radiology and Institute of Rehabilitation and Imaging of Brain Function, Nanchong Central Hospital, North Sichuan Medical College, Nanchong. [2]Department of Radiology, Xuanwu Hospital, Capital Medical University.

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通讯作者：

通讯机构： [1]Department of Radiology and Institute of Rehabilitation and Imaging of Brain Function, Nanchong Central Hospital, North Sichuan Medical College, Nanchong. [5]Department of Radiology, Peking University Third Hospital, Beijing. [*1]Department of Radiology and Institute of Rehabilitation and Imaging of Brain Function, Nanchong Central Hospital, North Sichuan Medical College, No. 97 South Renmin Road, Shunqing District, Nanchong 637000, Sichuan, China

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