资源类型：
期刊
WOS体系：
Review
Pubmed体系：
Journal Article
收录情况：
◇ SCIE
文章类型：
论著
机构：
[1]Department of Neurology, The Affiliated Hospital of Jining Medical University, Jining, China, 272000.
[2]Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, 100101.
[3]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China, 100053.
神经科系统
神经内科
首都医科大学宣武医院
[4]Department of Clinical Medicine, Jining Medical University, Jining, China, 272067.
[5]Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China, 310020.
ISSN：
1567-2050
关键词：
Metabolomics
metabolites
Alzheimer’s disease
gut microbiota
blood
摘要：
Growing evidence supports that Alzheimer's disease (AD) could be regarded as a metabolic disease, accompanying central and peripheral metabolic disturbance. Nowadays, exploring novel and potentially alternative hallmarks for AD is needed. Peripheral metabolites based on blood and gut may provide new biochemical insights about disease mechanisms. These metabolites can influence brain energy homeostasis, maintain gut mucosal integrity, and regulate the host immune system, which may further play a key role in modulating the cognitive function and behavior of AD. Recently, metabolomics has been used to identify key AD-related metabolic changes and define metabolic changes during AD disease trajectory. This review aims to summarize the key blood- and microbial-derived metabolites that are altered in AD and identify the potential metabolic biomarkers of AD, which will provide future targets for precision therapeutic modulation.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
被引次数：
1
WOS：
WOS:001111482900007
PubmedID：
37622711
中科院(CAS)分区：
出版当年[2022]版：
大类
|
4 区
医学
小类
|
4 区
神经科学
4 区
临床神经病学
最新[2023]版：
大类
|
4 区
医学
小类
|
4 区
临床神经病学
4 区
神经科学
JCR分区：
出版当年[2021]版：
Q3
CLINICAL NEUROLOGY
Q3
NEUROSCIENCES
最新[2023]版：
Q3
CLINICAL NEUROLOGY
Q4
NEUROSCIENCES
影响因子：
1.8
最新[2023版]
2.9
最新五年平均
3.04
出版当年[2021版]
4.064
出版当年五年平均
3.498
出版前一年[2020版]
2.1
出版后一年[2022版]
第一作者：
Sheng Can
第一作者机构：
[1]Department of Neurology, The Affiliated Hospital of Jining Medical University, Jining, China, 272000.
通讯作者：
Sheng Can;Yang Yan;Wang Xiaoni
推荐引用方式(GB/T 7714)：
Sheng Can,Chu Xu,He Yan,et al.Alterations in Peripheral Metabolites as Key Actors in Alzheimer's Disease[J].CURRENT ALZHEIMER RESEARCH.2023,20(6):379-393.doi:10.2174/1567205020666230825091147.
APA：
Sheng Can,Chu Xu,He Yan,Ding Qingqing,Jia Shulei...&Wang Xiaoni.(2023).Alterations in Peripheral Metabolites as Key Actors in Alzheimer's Disease.CURRENT ALZHEIMER RESEARCH,20,(6)
MLA：
Sheng Can,et al."Alterations in Peripheral Metabolites as Key Actors in Alzheimer's Disease".CURRENT ALZHEIMER RESEARCH 20..6(2023):379-393
