机构：[1]The National Clinical Research Center for Geriatric Disease, Xuanwu Hospital, Capital Medical University, 100053 Beijing, China首都医科大学宣武医院[2]Institute of Aging, Key Laboratory of Alzheimer’sDisease of Zhejiang Province, Zhejiang Clinical Research Center for Mental Disorders, School of Mental Health and The Affiliated Kangning Hospital, Wenzhou Medical University,Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou 325000 Zhejiang, China
Neuroinflammation is a key pathological feature in neurological diseases, including Alzheimer's disease (AD). The nucleotide-binding domain leucine-rich repeat-containing proteins (NLRs) belong to the pattern recognition receptors (PRRs) family that sense stress signals, which play an important role in inflammation. As a member of NLRs, the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) is predominantly expressed in microglia, the principal innate immune cells in the central nervous system (CNS). Microglia release proinflammatory cytokines to cause pyroptosis through activating NLRP3 inflammasome. The active NLRP3 inflammasome is involved in a variety of neurodegenerative diseases (NDs). Recent studies also indicate the key role of neuronal NLRP3 in the pathogenesis of neurological disorders. In this article, we reviewed the mechanisms of NLRP3 expression and activation and discussed the role of active NLRP3 inflammasome in the pathogenesis of NDs, particularly focusing on AD. The studies suggest that targeting NLRP3 inflammasome could be a novel approach for the disease modification.
基金：
Key Laboratory of Alzheimer's Disease of Zhejiang Province [ZJAD-2021004]; National Natural Science Foundation of China [82201576, 82293642, 82150710557, QML20210804]; Beijing Hospitals Authority Youth Programme [82230043]; Beijing Medical Research; Canada Research Chair in Alzheimer's Disease
第一作者机构：[1]The National Clinical Research Center for Geriatric Disease, Xuanwu Hospital, Capital Medical University, 100053 Beijing, China
通讯作者：
通讯机构：[1]The National Clinical Research Center for Geriatric Disease, Xuanwu Hospital, Capital Medical University, 100053 Beijing, China[2]Institute of Aging, Key Laboratory of Alzheimer’sDisease of Zhejiang Province, Zhejiang Clinical Research Center for Mental Disorders, School of Mental Health and The Affiliated Kangning Hospital, Wenzhou Medical University,Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou 325000 Zhejiang, China
推荐引用方式(GB/T 7714)：
Yao Jing,Wang Zhe,Song Weihong,et al.Targeting NLRP3 inflammasome for neurodegenerative disorders[J].MOLECULAR PSYCHIATRY.2023,28(11):4512-4527.doi:10.1038/s41380-023-02239-0.
医学