机构：[1]Department of Neurology, the First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.[2]Department of Emergency, Xuanwu Hospital, Capital Medical University, Beijing, China.内科系统急诊科首都医科大学宣武医院[3]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.神经科系统神经内科首都医科大学宣武医院[4]Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.
A proportion of acute ischemic stroke (AIS) patients suffer from early neurological deterioration (END) within 24 hours following intravenous thrombolysis (IVT), which greatly increases the risk of poor prognosis of these patients. Therefore, we aimed to explore the predictors of early neurological deterioration of ischemic origin (ENDi) in AIS patients after IVT and develop a nomogram prediction model. This study collected 244 AIS patients with post-thrombolysis ENDi as the derivation cohort and 155 patients as the validation cohort. To establish a nomogram prediction model, risk factors were identified by multivariate logistic regression analysis. The results showed that neutrophil to lymphocyte ratio (NLR) (OR 2.616, 95% CI 1.640-4.175, P < 0.001), mean platelet volume (MPV) (OR 3.334, 95% CI 1.351-8.299, P = 0.009), body mass index (BMI) (OR 1.979, 95% CI 1.285-3.048, P = 0.002) and atrial fibrillation (AF) (OR 8.012, 95% CI 1.341-47.873, P = 0.023) were significantly associated with ENDi. The area under the curve of the prediction model constructed from the above four factors was 0.981 (95% CI 0.961-1.000) and the calibration curve was close to the ideal diagonal line. Therefore, this nomogram prediction model exhibited good discrimination and calibration power and might be a reliable and easy-to-use tool to predict post-thrombolysis ENDi in AIS patients.
基金：
National Key R&D
Program of China (No. 2022YFC2408800) and National
Natural Science Foundation of China (No. 82171301,
81971114, 82274401)
第一作者机构：[1]Department of Neurology, the First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, the First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.[2]Department of Emergency, Xuanwu Hospital, Capital Medical University, Beijing, China.[3]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.[4]Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.[*1]First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121002, China.[*2]Xuanwu Hospital, No. 45 Changchun Street, Xicheng District, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Tian Tian,Wang Lanjing,Xu Jiali,et al.Prediction of early neurological deterioration in acute ischemic stroke patients treated with intravenous thrombolysis[J].JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM.2023,43(12):2049-2059.doi:10.1177/0271678X231200117.
APA：
Tian Tian,Wang Lanjing,Xu Jiali,Jia Yujie,Xue Kun...&Min Lianqiu.(2023).Prediction of early neurological deterioration in acute ischemic stroke patients treated with intravenous thrombolysis.JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,43,(12)
MLA：
Tian Tian,et al."Prediction of early neurological deterioration in acute ischemic stroke patients treated with intravenous thrombolysis".JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 43..12(2023):2049-2059
医学