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A large survey on COVID-19 vaccination in patients with Parkinson's disease and healthy population

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机构： [1]National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing, China [2]Department of Geriatrics Center, The Fourth People’s Hospital of Shenyang, Shenyang, Liaoning, China [3]Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China [4]Department of Neurology, Yueyang Central Hospital, Yueyang City, China [5]Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China [6]Department of Neurology, Baoding No.1 Central Hospital, Baoding, China [7]Department of Neurology, The Third Hospital of Jinan, Jinan, China [8]Department of Neurology, Zhumadian Central Hospital, Zhumadian, China [9]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China

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关键词： COVID-19 Vaccination Parkinson’s disease Health impact Confidence

摘要：

A full rollout of COVID-19 vaccination offers the most promising prospect of bringing the pandemic to an end. This study aimed to compare the coverage, safety, and confidence of COVID-19 vaccination between patients with Parkinson's disease (PD) and healthy individuals so as to give suggestions for future immunization programs.A web-based, nationwide, multicenter survey was carried out in China from 2021 to 2022. The age and sex-standardized vaccination rate was calculated. Multivariate stepwise logistic regression models were used to estimate the influencing factors of vaccination status. We also investigated vaccination safety, willingness, confidence, and reasons for hesitancy with some ad hoc questions.A total of 962 PD patients and 1208 healthy individuals participated in this survey with a vaccination rate of 71.1% vs 94.4% respectively. PD patients living in first-tier cities, with comorbidities, experiencing unstable PD with a longer course and levodopa use were less likely to get vaccinated, while healthy individuals living in first-tier cities and feeling physically poor exhibited a lower vaccination rate. For PD patients, concern about the adverse impact on existing illness and disagreement from doctors were the most common reasons for vaccination hesitancy. Whereas, no evidence was present that they experienced any local or systematic adverse events more frequently or seriously than healthy individuals, or their state of PD and comorbidities was seriously exacerbated after vaccination. A prominent transition from a little concerned to unconcerned about the security and efficacy of vaccines was evident among both two populations from pre-vaccination to post-vaccination.The COVID-19 vaccination rate was remarkably lower in PD patients than healthy individuals in China. The approved vaccines have shown an acceptable safety profile. Our findings would offer a reference to guide future clinical decision-making of COVID-19 vaccination and improve the immunization management of PD patients.Copyright © 2023 Elsevier Ltd. All rights reserved.

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出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区医学：研究与实验 3 区免疫学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区免疫学 3 区医学：研究与实验

JCR分区：

出版当年[2021]版：

Q3 IMMUNOLOGY Q3 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q2 IMMUNOLOGY Q2 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 4.5 最新[2023版] 3.7 最新五年平均 4.169 出版当年[2021版] 4.27 出版当年五年平均 3.641 出版前一年[2020版] 5.5 出版后一年[2022版]

第一作者：

第一作者机构： [1]National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing, China

通讯作者：

通讯机构： [9]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China [*1]Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Road, Beijing, 100053, China.

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A large survey on COVID-19 vaccination in patients with Parkinson's disease and healthy population

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