机构：[1]Department of Rehabilitation Medicine, Xuan Wu Hospital, Capital Medical University, No. 45 Chang Chun Street, Beijing 100053, China.神经科系统康复医学科首都医科大学宣武医院[2]Zhuhai UM Science & Technology Research Institute, No. 1889 Huandao East Road, Zhuhai 519031, China.
Frontal transcranial direct current stimulation (tDCS) and parietal tDCS are effective for treating disorders of consciousness (DoC); however, the relative efficacies of these techniques have yet to be determined. This paper compares the neuromodulation effects of frontal and parietal tDCS on DoC. Twenty patients with DoC were recruited and randomly assigned to two groups. One group received single-session frontal tDCS and single-session sham tDCS. The other group received single-session parietal tDCS and single-session sham tDCS. Before and after every tDCS session, we recorded coma recovery scale-revised (CRS-R) values and an electroencephalogram. CRS-R was also used to evaluate the state of consciousness at 9-12-month follow-up. Both single-session frontal and parietal tDCS caused significant changes in the genuine permutation cross-mutual information (G_PCMI) of local frontal and across brain regions (p < 0.05). Furthermore, the changes in G_PCMI values were significantly correlated to the CRS-R scores at 9-12-month follow-up after frontal and parietal tDCS (p < 0.05). The changes in G_PCMI and CRS-R scores were also correlated (p < 0.05). Both frontal tDCS and parietal tDCS exert neuromodulatory effects in DoC and induce significant changes in electrophysiology. G_PCMI can be used to evaluate the neuromodulation effects of tDCS.
基金：
STI2030-Major Projects (grant number: 2021ZD0204300),
the National Natural Science Foundation of China (grant numbers: 81873723 and 82102658), the
Beijing Natural Science Foundation (grant number: 7204267), and the Beijing Hospitals Authority
Youth Program (QML20230813).
第一作者机构：[1]Department of Rehabilitation Medicine, Xuan Wu Hospital, Capital Medical University, No. 45 Chang Chun Street, Beijing 100053, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Wan Xiaoping,Wang Yong,Zhang Ye,et al.A Comparison of the Neuromodulation Effects of Frontal and Parietal Transcranial Direct Current Stimulation on Disorders of Consciousness[J].BRAIN SCIENCES.2023,13(9):doi:10.3390/brainsci13091295.
APA：
Wan Xiaoping,Wang Yong,Zhang Ye&Song Weiqun.(2023).A Comparison of the Neuromodulation Effects of Frontal and Parietal Transcranial Direct Current Stimulation on Disorders of Consciousness.BRAIN SCIENCES,13,(9)
MLA：
Wan Xiaoping,et al."A Comparison of the Neuromodulation Effects of Frontal and Parietal Transcranial Direct Current Stimulation on Disorders of Consciousness".BRAIN SCIENCES 13..9(2023)
