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Progress in understanding the role of cGAS-STING pathway associated with programmed cell death in intervertebral disc degeneration

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收录情况： ◇ SCIE

作者：
Wang Zheng[1,2] * ; Hu Xinli[1,2] * ; Cui Peng[1,2] ; Kong Chao[1,2] ; Chen Xiaolong[1,2] ; Wang Wei[1,2] ; Lu Shibao[1,2] ;
机构： [1]Department of Orthopedics, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. [2]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
出处：
DOI： 10.1038/s41420-023-01607-7

摘要：
Nucleus pulposus (NP) inflammatory response can induce intervertebral disc degeneration (IVDD) by causing anabolic and catabolic disequilibrium of the extracellular matrix (ECM). This process is accompanied by the production of endogenous DNAs, then detectable by the DNA sensor cyclic GMP-AMP synthase (cGAS). cGAS recognizes these DNAs and activates the downstream adaptor protein, a stimulator of interferon genes (STING), initiating a cascade of inflammation responses through various cytokines. This evidence implies a crucial role of the cGAS-STING signaling pathway in IVDD. Additionally, it is suggested that this pathway could modulate IVDD progression by regulating apoptosis, autophagy, and pyroptosis. However, a detailed understanding of the role of cGAS-STING pathway in IVDD is still lacking. This review provides a comprehensive summary of recent advances in our understanding of the role of the cGAS-STING pathway in modulating inflammatory response in IVDD. We delve into the connection between the cGAS-STING axis and apoptosis, autophagy, and pyroptosis in IVDD. Furthermore, we discuss the therapeutic potential of targeting the cGAS-STING signaling pathway in IVDD treatment. Overall, this review aims to provide a foundation for future directions in IVDD treatment strategies.© 2023. Cell Death Differentiation Association (ADMC).

基金：
National Key Research and Development Program of China (No. 2020YFC2004900), National Natural Science Foundation of China (H0608), Natural Science Foundation of China (No. 81672201, 81871794) and Beijing Hospitals Authorit’Ascent Plan (No. DFL20190802).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 3 区 细胞生物学
最新[2023]版：
大类 | 2 区 生物学
小类 | 2 区 细胞生物学
JCR分区：
出版当年[2021]版：
Q2 CELL BIOLOGY
最新[2023]版：
Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Orthopedics, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. [2]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Orthopedics, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. [2]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
推荐引用方式(GB/T 7714)：
Wang Zheng,Hu Xinli,Cui Peng,et al.Progress in understanding the role of cGAS-STING pathway associated with programmed cell death in intervertebral disc degeneration[J].CELL DEATH DISCOVERY.2023,9(1):doi:10.1038/s41420-023-01607-7.
APA：
Wang Zheng,Hu Xinli,Cui Peng,Kong Chao,Chen Xiaolong...&Lu Shibao.(2023).Progress in understanding the role of cGAS-STING pathway associated with programmed cell death in intervertebral disc degeneration.CELL DEATH DISCOVERY,9,(1)
MLA：
Wang Zheng,et al."Progress in understanding the role of cGAS-STING pathway associated with programmed cell death in intervertebral disc degeneration".CELL DEATH DISCOVERY 9..1(2023)

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