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Integration of transcriptomics reveals ferroptosis-related signatures and immune cell infiltration in bronchopulmonary dysplasia

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机构： [1]Department of Pediatrics, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (Preparatory Stage), Shanghai, China. [2]Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. [3]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China. [4]Department of Pediatric Nephrology, Wuxi Children's Hospital, Wuxi, China. [5]Department of Neonatology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

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关键词： Bronchopulmonary dysplasia Diagnostic Ferroptosis Immune infiltration Prediction model

摘要：

Ferroptosis has emerged as a significant factor in the development of bronchopulmonary dysplasia (BPD). Nevertheless, our understanding of the potential involvement of ferroptosis-related genes (FRGs) in BPD remains incomplete. In this study, we leveraged the Gene Expression Omnibus (GEO) database to investigate this aspect. We identified 20 differentially expressed FRGs that are associated with BPD, shedding light on their potential role in the condition.LASSO along with SVM-RFE algorithms found that 12 genes: MEG3, ACSL1, DPP4, GALNT14, MAPK14, CD82, SMPD1, NR1D1, PARP3, ACVR1B, H19, and SLC7A11 were closely related to ferroptosis modulation and immunological response. These genes were used to create a nomogram with good predictive power and were found to be involved in BPD-linked pathways. In addition, the marker genes-based prediction model performed well in external validation data sets. The study also showed a significance between BPD and control samples in terms of immune cell infiltration. These findings may help improve our understanding of FRGs in BPD and lead to the development of more effective immunotherapies.© 2023 The Authors.

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出版当年[2022]版：

大类 | 4 区综合性期刊

小类 | 4 区综合性期刊

最新[2023]版：

大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

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出版当年[2021]版：

Q2 MULTIDISCIPLINARY SCIENCES

最新[2023]版：

Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 3.4 最新[2023版] 3.9 最新五年平均 3.776 出版当年[2021版] 3.752 出版当年五年平均 0 出版前一年[2020版] 4 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Pediatrics, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (Preparatory Stage), Shanghai, China.

通讯作者：

通讯机构： [2]Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. [5]Department of Neonatology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. [*1]Department of Neonatology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China. [*2]Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210009, China.

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