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Risk factors for anastomotic leak and postoperative morbidity after right hemicolectomy for colon cancer: results from a prospective, multi-centre, snapshot study in China

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机构: [1]Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center of Digestive Diseases, Beijing, China. [2]Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China. [3]Department of Geriatric Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China. [4]Department of Gastrointestinal Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. [5]Department of Colorectal Oncology, Fourth General Surgery Department, Shengjing Hospital, China Medical University, Shenyang, China. [6]Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. [7]Department of General Surgery, China-Japan Friendship Hospital, Beijing, China. [8]Department of General Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. [9]Department of General Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China. [10]Department of General Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China. [11]Department of Gastrointestinal Surgery, The First Hospital of Shanxi Medical University, Taiyuan, China. [12]Department of Gastrointestinal Surgery, Beijing Hospital, National Center of Gerontology, Beijing, China. [13]Department of Gastrointestinal Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China. [14]Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. [15]Department of General Surgery, First Affiliated Hospital of Soochow University, Soochow, China. [16]Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, China. [17]Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. [18]Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China. [19]Department of General Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. [20]Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. [21]Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. [22]Department of Gastrointestinal Surgery, Guangdong Provincial People's Hospital, Guangzhou, China. [23]Department of General Surgery, Guangdong Provincial People's Hospital, Guangzhou, China. [24]Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China. [25]Department of General Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China. [26]Department of Gastrointestinal Surgery, The First Affiliated Hospital of Air Force Military Medical University, Xi'an, China. [27]Department of General Surgery, Center for Minimally Invasive Gastrointestinal Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China. [28]Department of General Surgery, Tangdu Hospital, The Air Force Medical University, Xi'an, China. [29]Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. [30]Department of Colorectal Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. [31]Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, China. [32]Department of Gastrointestinal Surgery, The Affiliated Nanchong Central Hospital of North Sichuan Medical College, Nanchong, China. [33]Department of Colorectal Surgery, Changhai Hospital, Navy Military Medical University, Shanghai, China. [34]Department of Colorectal Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. [35]Department of General Surgery, Daping Hospital, Army Medical University, Chongqing, China. [36]Department of Colorectal Surgery, Zhongshan hospital, Fudan University, Shanghai, China. [37]Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. [38]Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. [39]Department of General Surgery, Peking University First Hospital, Beijing, China. [40]Department of Gastrointestinal Surgery, The First Hospital of China Medical University, Shenyang, China. [41]Department of General Surgery, Peking University Third Hospital, Beijing, China. [42]Department of Gastroenterological Surgery, Peking University People's Hospital, Beijing, China. [43]Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. [44]Department of Gastrointestinal Surgery, Yongchuan Hospital of Chongqing Medical University, Chongqing, China. [45]Department of Gastrointestinal Surgery, Tongji Hospital, Medical College of Tongji University, Shanghai, China. [46]General Surgery, Cancer Center, Department of Colorectal Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China. [47]Department of General Surgery, Shaanxi Provincial People's Hospital, Xi'an, China. [48]Department of General Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. [49]Department of General Surgery, Xuanwu hospital Capital Medical University, Beijing, China. [50]Department of General Surgery, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China. [51]Department of Gastrointestinal Surgery (Surgical Oncology), Affiliated Hospital of Qinghai University, Xining, China. [52]Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands.
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Right hemicolectomy is the standard treatment for right-sided colon cancer. There is variation in the technical aspects of performing right hemicolectomy as well as in short-term outcomes. It is therefore necessary to explore best clinical practice following right hemicolectomy in expert centres.This snapshot study of right hemicolectomy for colon cancer in China was a prospective, multicentre cohort study in which 52 tertiary hospitals participated. Eligible patients with stage I-III right-sided colon cancer who underwent elective right hemicolectomy were consecutively enrolled in all centres over 10 months. The primary endpoint was the incidence of postoperative 30-day anastomotic leak.Of the 1854 patients, 89.9 per cent underwent laparoscopic surgery and 52.3 per cent underwent D3 lymph node dissection. The overall 30-day morbidity and mortality were 11.7 and 0.2 per cent, respectively. The 30-day anastomotic leak rate was 1.4 per cent. In multivariate analysis, ASA grade > II (P < 0.001), intraoperative blood loss > 50 ml (P = 0.044) and D3 lymph node dissection (P = 0.008) were identified as independent risk factors for postoperative morbidity. Extracorporeal side-to-side anastomosis (P = 0.031), intraoperative blood loss > 50 ml (P = 0.004) and neoadjuvant chemotherapy (P = 0.004) were identified as independent risk factors for anastomotic leak.In high-volume expert centres in China, laparoscopic resection with D3 lymph node dissection was performed in most patients with right-sided colon cancer, and overall postoperative morbidity and mortality was low. Further studies are needed to explore the optimal technique for right hemicolectomy in order to improve outcomes further.© The Author(s) 2023. Published by Oxford University Press on behalf of BJS Society Ltd.

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大类 | 1 区 医学
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大类 | 1 区 医学
小类 | 1 区 外科
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第一作者机构: [1]Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center of Digestive Diseases, Beijing, China.
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通讯机构: [1]Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center of Digestive Diseases, Beijing, China. [*1]Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center of Digestive Diseases, No.95 Yongan Road, Xicheng District, Beijing 100050, China
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