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Generation and characterization of induced pluripotent stem cell lines derived from skin fibroblasts of patients with adrenoleukodystrophy

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收录情况： ◇ SCIE

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机构： [1]Medical Schoo of Chinese PLA, Beiing 100853, China [2]Senior Department of Pediatrics, Chinese PLA General Hospital, Department of Pediatrics, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, [3]CXuanwu Hospital Capital Medical University, Bejing, China [4]Beijing Institute for Brain Disorders, Center for Brain Disorders Research, Caqpital Medical University, Bejing, China

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X-linked adrenoleukodystrophy (ALD) is a rare peroxisome disease with phenotypic heterogeneity. There is a lack of suitable in vitro models to study its pathogenesis. We established two strains of iPSCs from skin fibroblasts of patients with childhood cerebral ALD and Addison's disease, respectively. CytoTune™2.0 Sendai reprogramming kit was used. The iPSC lines showed typical stem cell morphology, normal karyotype, and carrying ABCD1 variation. The iPSC lines express pluripotency markers, and have the capacity to differentiate into three germ layers. iPSCs can be used as an alternative cell source for ALD in vitro model to study its pathogenesis and therapeutic strategies.Copyright © 2023. Published by Elsevier B.V.

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出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区生物工程与应用微生物 4 区细胞与组织工程 4 区细胞生物学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区生物工程与应用微生物 4 区细胞与组织工程 4 区细胞生物学

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出版当年[2021]版：

Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q4 CELL & TISSUE ENGINEERING Q4 CELL BIOLOGY

最新[2023]版：

Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q4 CELL & TISSUE ENGINEERING Q4 CELL BIOLOGY

影响因子： 0.8 最新[2023版] 1.1 最新五年平均 1.587 出版当年[2021版] 2.138 出版当年五年平均 2.02 出版前一年[2020版] 1.2 出版后一年[2022版]

第一作者：

第一作者机构： [1]Medical Schoo of Chinese PLA, Beiing 100853, China [2]Senior Department of Pediatrics, Chinese PLA General Hospital, Department of Pediatrics, The First Medical Center of Chinese PLA General Hospital, Beijing 100853,

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通讯作者：

通讯机构： [1]Medical Schoo of Chinese PLA, Beiing 100853, China [2]Senior Department of Pediatrics, Chinese PLA General Hospital, Department of Pediatrics, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, [4]Beijing Institute for Brain Disorders, Center for Brain Disorders Research, Caqpital Medical University, Bejing, China [*1]Medical School of Chinese PLA, China ,Senior Department of Pediatrics, Chinese PLA General Hospital, Department of Pediatrics, The First Medical Center of Chinese PLA General Hospital, Beiing 100853, China.

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