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Unveiling the link between systemic inflammation markers and cognitive performance among older adults in the US: A population-based study using NHANES 2011-2014 data

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机构： [1]Centre for Precision Health, Edith Cowan University, Perth, Australia [2]Department of Clinical Laboratory, Tai’an City Public Health Medical Center, Tai’an, China [3]Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China [4]Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, [5]Department of Bioinformatics, Thrive Bioresearch, Beijing, China [6]Department of Radiotherapy, The Affiliated Tai’an City Central Hospital of Qingdao University, Tai’an, China

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This study aimed to evaluate the association between systemic inflammation markers and cognitive performance among older US adults.This cross-sectional study assessed 3,632 older participants from the 2011-2014 National Health and Nutrition Examination Survey (NHANES). The main analysis included participants aged over 60 years. Systemic inflammation markers were quantified by calculating the composite inflammation indicators from the blood routine count, and cognitive performance was assessed using Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test, Animal Fluency test (AFT), and Digit Symbol Substitution test (DSST).There were 2,743 individuals enrolled in the current analysis. The overall mean age was 64.9 years and 48.7 % were males. The levels of SIRI and PIV were significant negative associated with scores of CERAD, CERAD delayed recall, and DSST in the unadjusted models. Moreover, SII were significant negative associated with scores of CERAD and CERAD delayed recall. After adjusting the covariates of demographics, lifestyle factors, history of chronic diseases and BMI, significant negative association were observed between systematic inflammation markers and cognitive performance. Additionally, a progressive and significant decrease in the score of cognitive performance assessments with the increased levels of SIRI, SII, and PIV were respectively observed. Finally, the correlation between systemic inflammation markers and cognitive performance were evidenced in the sensitive analysis.Findings support a strong inverse correlation between systemic inflammation markers and cognitive performance, suggesting that addressing inflammation could be a promising avenue for enhancing cognitive health and mitigating age-related cognitive decline.Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

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出版当年[2022]版：

Q4 CLINICAL NEUROLOGY Q4 NEUROSCIENCES

最新[2023]版：

Q3 CLINICAL NEUROLOGY Q4 NEUROSCIENCES

影响因子： 1.9 最新[2023版] 1.9 最新五年平均 2 出版当年[2022版] 2.1 出版当年五年平均 2.116 出版前一年[2021版] 1.9 出版后一年[2023版]

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第一作者机构： [1]Centre for Precision Health, Edith Cowan University, Perth, Australia

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通讯机构： [1]Centre for Precision Health, Edith Cowan University, Perth, Australia [*1]Centre for Precision Health, Edith Cowan University, 270 Joondalup Dr, Joondalup, WA 6027, Australia.

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