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Spinal cord injury-induced gut dysbiosis influences neurological recovery partly through short-chain fatty acids

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Jing Yingli[1,2] * ; Yang Degang[1,2,3] * ; Bai Fan[1,2] ; Wang Qiuying[1,2] ; Zhang Chao[4] ; Yan Yitong[1,2] ; Li Zihan[1,2] ; Li Yan[1,2] ; Chen Zhiguo[2,5] ; Li Jianjun[1,2] ; Yu Yan[1,2] ;
机构： [1]China Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, and School of Rehabilitation Medicine,Capital Medical University, Beijing 100068, China [2]Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100068, China [3]Department of Spinal andNeural Function Reconstruction, Beijing Bo’ai Hospital, Beijing 100068, China [4]Department of Neurosurgery, Linyi People’s Hospital, Shangdong 276034, China [5]Cell TherapyCenter, Beijing Institute of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, and Key Laboratory ofNeurodegenerative Diseases, Ministry of Education, Beijing 100053, China
出处：
DOI： 10.1038/s41522-023-00466-5
ISSN：

摘要：
Spinal cord injury (SCI) can reshape gut microbial composition, significantly affecting clinical outcomes in SCI patients. However, mechanisms regarding gut-brain interactions and their clinical implications have not been elucidated. We hypothesized that short-chain fatty acids (SCFAs), intestinal microbial bioactive metabolites, may significantly affect the gut-brain axis and enhance functional recovery in a mouse model of SCI. We enrolled 59 SCI patients and 27 healthy control subjects and collected samples. Thereafter, gut microbiota and SCFAs were analyzed using 16 S rDNA sequencing and gas chromatography-mass spectrometry, respectively. We observed an increase in Actinobacteriota abundance and a decrease in Firmicutes abundance. Particularly, the SCFA-producing genera, such as Faecalibacterium, Megamonas, and Agathobacter were significantly downregulated among SCI patients compared to healthy controls. Moreover, SCI induced downregulation of acetic acid (AA), propionic acid (PA), and butyric acid (BA) in the SCI group. Fecal SCFA contents were altered in SCI patients with different injury course and injury segments. Main SCFAs (AA, BA, and PA) were administered in combination to treat SCI mice. SCFA supplementation significantly improved locomotor recovery in SCI mice, enhanced neuronal survival, promoted axonal formation, reduced astrogliosis, and suppressed microglial activation. Furthermore, SCFA supplementation downregulated NF-κB signaling while upregulating neurotrophin-3 expression following SCI. Microbial sequencing and metabolomics analysis showed that SCI patients exhibited a lower level of certain SCFAs and related bacterial strains than healthy controls. SCFA supplementation can reduce inflammation and enhance nourishing elements, facilitating the restoration of neurological tissues and the improvement of functional recuperation. Trial registration: This study was registered in the China Clinical Trial Registry ( www.chictr.org.cn ) on February 13, 2017 (ChiCTR-RPC-17010621).© 2023. The Author(s).

基金：
The present study was funded by the National Natural Science Foundation of China [grant numbers 82271433, 81901272]; the Special Fund for Basic Scientific Research of Central Public Research Institutes [grant numbers 2020cz-8, 2021cz-8]; the Beijing Municipal Science and Technology Commission [grant number Z171100001017076]; the Fund of Postdoctoral Innovation Program of Shandong Province [grant number 202103064]; and the Linyi People’s Hospital Doctoral Research Foundation [grant number 2021LYBS05].
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 生物学
小类 | 1 区 生物工程与应用微生物 1 区 微生物学
最新[2023]版：
大类 | 1 区 生物学
小类 | 1 区 生物工程与应用微生物 1 区 微生物学
JCR分区：
出版当年[2021]版：
Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q1 MICROBIOLOGY
最新[2023]版：
Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q1 MICROBIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]China Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, and School of Rehabilitation Medicine,Capital Medical University, Beijing 100068, China [2]Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100068, China
共同第一作者：
通讯作者：
通讯机构： [1]China Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, and School of Rehabilitation Medicine,Capital Medical University, Beijing 100068, China [2]Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100068, China [5]Cell TherapyCenter, Beijing Institute of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, and Key Laboratory ofNeurodegenerative Diseases, Ministry of Education, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Jing Yingli,Yang Degang,Bai Fan,et al.Spinal cord injury-induced gut dysbiosis influences neurological recovery partly through short-chain fatty acids[J].NPJ BIOFILMS AND MICROBIOMES.2023,9(1):doi:10.1038/s41522-023-00466-5.
APA：
Jing Yingli,Yang Degang,Bai Fan,Wang Qiuying,Zhang Chao...&Yu Yan.(2023).Spinal cord injury-induced gut dysbiosis influences neurological recovery partly through short-chain fatty acids.NPJ BIOFILMS AND MICROBIOMES,9,(1)
MLA：
Jing Yingli,et al."Spinal cord injury-induced gut dysbiosis influences neurological recovery partly through short-chain fatty acids".NPJ BIOFILMS AND MICROBIOMES 9..1(2023)

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